Infectious disease pt.1

Antibiotics yay

Amoxicillin Class

Penicillins

Amoxicillin Formulations

Caps - Amoxil, pulv. for oral susp., Tabs, Chewable tabs.

Amoxacillin MOA

Beta-lactam, inhibits synthesis of bacterial cell wall by binding to penicillin binding proteins

Amoxicillin Indications

Bacterial infections: otitis media, prophylaxis for endocarditis, Pharyngitis.

Amoxicillin Common adverse effects

N/V/D, rash, headache, yeast infection

Amoxicillin Severe adverse effects

SJS, TEN, C-Diff

Amoxicillin Box Warnings

None

Amoxicillin contraindications

Hypersensitivity such as SJS or anaphylaxis to beta-lactams

Amoxicillin/Clavulanate Class

PCNs

Amoxicillin/Clavulanate Formulations

Tabs - Augmentin, pulv. for oral sups., chewable tabs, ER tabs.

Amoxicillin/Clavulanate Indications

Bacterial Infections: otitis media, sinusitis, pneumonia,

Amoxicillin/Clavulanate MOA

beta-lactam: inhibition of cell walls, Clavulanate: beta-lactamase inhibitor.

Amoxicillin/Clavulanate Common Side Effects

N/V/D, Rash, Headache, yeast infection,

Amoxicillin/Clavulanate Severe adverse effect

SJS, TEN, C-Diff

Amoxicillin/Clavulanate Box warnings

None

Amoxicillin/Clavulanate Contraindications

SJS or anaphylaxis to beta-lactams, hepatotoxicity, increased liver function tests, Jaundice or hepatic disfunction, renal impairment and hemodialysis (ER only).

PCN counseling

Report abnormal diarrhea, finish all unless otherwise instructed, store susp. properly, stop and report if reaction occur, may cause rash or N/V/D. Augmentin - W/ food