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Hairy Cell Leukemia is primarily driven by the __ mutation.

B-RAF V600E

The mutation leading to abnormal activation of the __ pathway causes uncontrolled cell growth in Hairy Cell Leukemia.

MAPK/ERK

Hairy cells secrete __, which activates fibroblasts and leads to marrow fibrosis.

TGF-β

The main consequence of bone marrow infiltration by hairy cells is the suppression of normal __.

hematopoiesis

Splenomegaly in Hairy Cell Leukemia leads to __ due to trapping and destroying blood cells.

hypersplenism

In Hairy Cell Leukemia, a dry tap on bone marrow aspiration is often indicative of marrow __.

fibrosis

Hairy Cell Leukemia can cause __, leading to an increase in infections due to decreased white blood cells.

neutropenia

The presence of distinctive 'hairy' lymphocytes is a key feature of __.

Hairy Cell Leukemia

First-line therapies for Hairy Cell Leukemia include Cladribine and __.

Pentostatin

The B-RAF V600E mutation serves as an important __ marker for Hairy Cell Leukemia.

diagnostic