drug quiz

adalimumab brand

humira

adalimumab use

rheumatoid arthritis, ankylosing spondylitis, crohn's disease, ulcerative colitis

adalimumab MOA

binds and inhibits tumor necrosis factor alpha, reducing inflammation and altering immune response

adalimumab BBW

increased risk of serious infections. lymphoma or other malignancies may also occur.

alendronate brand

fosamax

alendronate use

osteoporosis

alendronate MOA

inhibits osteoclast activity, reducing bone resorption and turnover

alendronate BBW

none

allopurinol brand

zyloprim

allopurinol uses

hyperuricemia, gout prophylaxis

allopurinol MOA

inhibits xanthine oxidase, interfering with uric acid production

allopurinol BBW

none

carbamazepine brand

epitol, tegretol, tegretol XR

carbamazepine uses

seizure disorder, trigeminal neuralgia

carbamazepine MOA

reduces post-tetanic potentiation, decreasing seizure spread

carbamazepine BBW

risk of severe blood disorders and dermatological reactions

celecoxib brand

celebrex

celecoxib uses

osteoarthritis, rheumatoid arthritis, dysmenorrhea, pain

celecoxib MOA

selectively inhibits cyclooxygenase-2 and reduces prostaglandin synthesis (COX-2 inhibitor)

celecoxib BBW

may increase risk of CV thrombotic events, may increase risk of fatal GI events

clindamycin brand

cleocin

clindamycin uses

bacterial infections

clindamycin MOA

inhibits protein synthesis

clindamycin BBW

risk of severe diarrhea and c. diff infection

colchicine brand

colcrys, mitigare, gloperba

colchicine uses

treatment and prevention of gout

colchicine MOA

prevents neutrophil migration and activity related to gout

colchicine BBW

none

diclofenac brand

voltaren, voltaren XR

diclofenac uses

osteoarthritis, rheumatoid arthritis

diclofenac MOA

inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis

diclofenac BBW

may increase risk of CV thrombotic events, may increase risk of fatal GI events

doxycycline brand

doryx, monodox, periostat, vibramycin

doxycycline uses

bacterial infections

doxycycline MOA

inhibits protein synthesis

doxycycline BBW

risk of severe diarrhea and c. diff infection

estradiol brand

estrace

estradiol use

menopause, hypoestrogenism

estradiol MOA

binds to estrogen receptors

estradiol BBW

may increase risk of endometrial cancer, stroke, MI, and breast cancer, may increase risk of dementia in post-menopausal women

hydrocortisone brand

cortef, cortizone, hytone, cortenema, proctocort

hydrocortisone uses

adrenal insufficiency, dermatoses, ulcerative colitis, hemorrhoids

hydrocortisone MOA

inhibits inflammatory cytokines, produces multiple glucocorticoid and mineralocorticoid effects

hydrocortisone BBW

none

hydroxychloroquine brand

plaquenil

hydroxychloroquine uses

rheumatoid arthritis, malaria, covid-19 (investigational)

hydroxychloroquine MOA

exact mechanism not known

hydroxychloroquine BBW

prescribers must be familiar with complete prescribing guidelines before use

ibuprofen brand

advil, motrin IB

ibuprofen uses

fever, pain, osteoarthritis, rheumatoid arthritis

ibuprofen MOA

inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis

ibuprofen BBW

may increase risk of CV thrombotic events, may increase risk of GI events

ketorolac brand

toradol, toradol IM/IV, sprix

ketorolac uses

moderate to severe pain, migraine headache

ketorolac MOA

inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis

ketorolac BBW

oral - up to 5 days treatment and only after parenteral use all - may increase risk of CV thrombotic events; may increase risk of fatal GI events

lamotrigine brand

lamictal, lamictal XR

lamotrigine uses

bipolar disorder, partial seizures

lamotrigine MOA

inhibits voltage-gated sodium channels, decreasing presynaptic glutamate and aspartate release

lamotrigine BBW

serious rashes requiring hospitalization may develop

meloxicam brand

mobic

meloxicam uses

osteoarthritis, rheumatoid arthritis

meloxicam MOA

inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis

meloxicam BBW

may increase risk of CV thrombotic events, may increase risk of fatal GI events

methotrexate brand

otrexup, rasuvo, trexall

methotrexate uses

leukemia, lymphoma, cancer, rheumatoid arthritis, psoriasis

methotrexate MOA

immunosuppressant, inhibits dihydrofolate reductase

methotrexate BBW

only for severe disease. fetal death/birth defects, impaired drug elimination, hepatotoxicity, pulmonary toxicity, malignant lymphoma, and skin reactions

methylprednisolone brand

medrol

methylprednisolone uses

asthma, inflammation

methylprednisolone MOA

inhibits multiple inflammatory cytokines, produces multiple glucocorticoid and mineralocorticoid effects

methylprednisolone BBW

none

minocycline brand

minocin, solodyn

minocycline uses

bacterial infections

minocycline MOA

inhibits nucleic acid synthesis

minocycline BBW

none

naproxen brand

naprosyn, EC naprosyn, naprelan

naproxen uses

osteoarthritis, rheumatoid arthritis

naproxen MOA

inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis

naproxen BBW

may increase risk of CV thrombotic events, may increase risk of GI events

prednisolone brand

orapred, orapred ODT, pediapred, etc.

prednisolone uses

asthma, inflammation, adrenal insufficiency, gout, MS

prednisolone MOA

inhibits multiple inflammatory cytokines, produces multiple glucocorticoid and mineralocorticoid effects

prednisolone BBW

none

prednisone brand

sterapred, sterapred DS

prednisone uses

asthma, inflammation, adrenal insufficiency, gout, MS

prednisone MOA

inhibits multiple inflammatory cytokines, produces multiple glucocorticoid and mineralocorticoid effects

prednisone BBW

none

progesterone brand

prometrium, crinone, procheive, endometrin

progesterone uses

amenorrhea, endometrial hyperplasia prevention, postmenopausal

progesterone MOA

inhibits pituitary gonadotropin release, transforms proliferative into secretory endometrium

progesterone BBW

do not use in CV disease or dementia, increased breast cancer risk

tramadol brand

conzip, qdolo, ultram

tramadol uses

pain, moderate to moderate-severe

tramadol MOA

binds to mu receptors and weakly inhibits norepinephrine/serotonin reuptake, producing analgesia (central opioid agonist)

tramadol BBW

high addiction/misuse risk, opioid analgesic REMS, life-threatening respiratory depression can occur, concomitant use with BZDP

triamcinolone topical brand

kenalog

triamcinolone topical uses

dematoses

triamcinolone topical MOA

inhibits multiple inflammatory cytokines, produces multiple glucocorticoid and mineralocorticoid effects

triamcinolone topical BBW

none