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Cysteine (from methionine and serine) and proline (from glutamate)
Premature infants
Tyrosine (from phenylalanine) and cystenine (from methionine)
Infants with premature liver function or liver disease (cirrhosis)
Tyrosine (from phenylalanine)
PKU (phenylketonuria), lack of phenylalanine or hydroxylase
Arginine (from glutamine, glutamate, proline)
Trauma
Products of protein digestion in the stomach
large polypeptides, some oligopeptides (2-20 AAs) and free AAs
Products of protein digestion in the small intestine
short oligopeptide fragments, dipeptides, AAs
What hormones/neurotransmitters can tryptophan make?
Serotonin→ melatonin
What hormones/neurotransmitters can glutamate make?
GABA
What hormones/neurotransmitters can glutamate, glycine, and cystenine make?
Glutathione
What hormones/neurotransmitters can tyrosine make?
Dopamine→norepinephrine→epinephrine
What hormones/neurotransmitters can methionine make?
S-adenosyl methionine (SAM), primary methyl donor
phenylalanine hydroxylase
phenylketonuria (PKU)
tyrosine aminotransferase
Tyrosine aminotransferase
homogentisate dioxygenase
alkoptonuria
decreased activity of the branched-chain α-ketoacid dehydrogenase (BCKAD) complex, mainly leucine
Maple Syrup Urine Disease (MSUD)
cystathionine α synthase
Hyperhomocysteinemia
methionine adenosyl transferase
Hypermethioninemia