continued use of substances despite adverse consequences
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Abuse
use for purposes of intoxication or beyond intended use
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Withdrawal
symptoms occurring when substance no longer used
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Tolerance
a gradual decrease in the action of a drug at a given dose in the blood
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Alcohol
CNS depressant: mild sedation, coma, respiratory failure, death
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Wernicke encephalopathy
a degenerative brain disorder caused by thiamine deficiency. Characterized by vision impairment, ataxia, hypotension, confusion, and coma
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Korsakoff’s amnestic syndrome
a problem associated with alcoholism and is associated with impairment of understanding new information and retrieving memories
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Wernicke-Korsakoff syndrome
a memory disorder that results from a thiamine deficiency. Early symptoms can be reversed but if not, prognosis is poor
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Disulfiram
a medication that is used as a deterrent from drinking as it produces episodes of severe nausea and vomiting if alcohol is injested.
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Naltrexone
a medication used for treatment of alcohol and heroin abuse. reduces the craving for alcohol
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Alcohol withdrawal syndrome - Stage 1
increased HR, temperature, and slightly elevated BP. Slight diaphoresis, impaired appetite, hand tremors
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Alcohol withdrawal syndrome - Stage 2
high HR, BP, and temp. obvious diaphoresis, intermittent confusion, some visual and auditory hallucinations, painful anxiety and restlessness, tremors
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Alcohol withdrawal syndrome - Stage 3
Very high HR, BP, and temp. marked diaphoresis, disorientation/confusion, disturbing visual and auditory hallucinations, agitation, panic states, uncontrollable tremors, convulsions are common
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Cocaine class
CNS stimulant - increases dopamine, norepinephrine, and serotonin
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Cocaine effect
sudden burst of mental alertness and energy, feelings of self-confidence and being in control, sociability
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Withdrawal of cocaine
Severe anxiety, restlessness, and agitation
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long term use of cocaine
leads to depletion of norepinephrine leading to “crash” and sleeping 12 to 18 hours
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Amphetamine
block reuptake of norepinephrine and dopamine
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Methamphetamine
release of excess dopamine, highly addictive, used in a binge and crash pattern
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MDMA (ecstasy)
increased serotonin and excess dopamine release cause hallucinations, confusion, and sleep problems
possible malignant hyperthermia
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Nicotine
stimulation nervous systems to increase alertness, concentration, attention, and appetite suppression