Ch5-12 (advancements in treating MDD - bipolar syndrome)

Ketamine is an ____ receptor

NMDA

Auvelity (dexatromethorphan and bupropion) - first ____ ____receptor ______

oral, NMDA, antagonist

psychedelics (psilocybn) - promote _____

neuroplasticity

transcranial magnetic stimulation - ____ fields to stimulate ____ cells

magnetic, nerve

neurosteriods - modulate _____ receptors

GABA

botox -____ release of ach

block

classic treatment of bipolar syndrome

lithium

lithium treatment likely works through interference with ____ channels

Na

lithium is eliminated by the_____

kidneys

accumulation of lithium = ______

lithium toxicity

3 levels of lithum toxicity

mild, moderate, severe

mild lithium toxicity = _____ taste, fine ____, nausea, _____

metalic, tremor, weakness

moderate lithium toxicity = vomitting, _____, increase ____, dizziness, _____, ____ vision

nausea, tremor, incoordination, blurred

antipsychotic = ____ receptor _____

dopamine, antagonist

clozapine, risperidone

antipsychotic

carbamazepine, valproic acid, gabapentin, lamotringe

antiseizure drugs

antiseizure drugs - effect _____ channels

Na

second generation drugs have ____ side effects

decreased

aripiprazole, cariprazine, lumateperone

second generation antipsychotics

gene therapy treatmenr - _____ gene

AKAP11

other ways to treat bipolar disorder

• _____ injectables

• ____ therapy

• _____

long acting, gene, TMS

drug to manage weight gain associated with antipsychotics

metformin