Review for Mastery

Content that I doubted when taking an exam or quiz for review

What does a lowered FEV1/FVC ratio mean?

Obstruction is present

What does the anti-CCP typically show?

Disease toward rheumatoid arthritis

Define this:

The active drug separates from its physical pill, capsule, or liquid form so it can dissolve in the body

Liberation

Define this:

The drug moves from where you took it (like your gut or skin) into your bloodstream

Absorption

Define this:

The blood carries the drug throughout the body to various organs and tissues

Distribution

Define this:

Enzymes (mostly in the liver) chemically change the drug into simpler compounds that are easier to remove

Metabolism

Define this:

The body flushes out the leftover drug or its byproducts, mostly through urine, bile, or breath.

Excretion

What is the brand name for tocilizumab?

Actemra

What is the drug class for celecoxib?

COX-2 selective NSAID

Why does celecoxib target COX-2 NSAID?

Due to the structure, its has a larger binding affinity for the COX-2 specificity pocket but too large for COX-1

What is the drug target for beta2-adrenegic antagonist and M3 agonist?

Bronchiolar smooth muscle cells (SMCs)