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265
Hiero II of Syracuse lays siege to the Mamertines, a group of Campanian mercenaries holding Messina in Sicily
264
The consul Appius Claudius Caudex invests Messina in support of the Mamertines
264–241
First Punic War
260s
Under Nicomedes I Bithynia achieves independence from the Seleucids
263
Under Eumenes I Pergamum achieves independence from the Seleucids
262
Roman siege of Agrigentum
261
Battle of Mylae
259–253
Second Syrian War between Ptolemy II and Antiochus II
255, 253, 249
Major shipwrecks of the Roman fleet around Sicily
250s
Under Ariarathes III Cappadocia achieves independence from the Seleucids
246
Deaths of Ptolemy II and Antiochus II
246–241
Third Syrian War between Ptolemy III and Laodike, widow of Antiochus II and mother of Seleucus II and Antiochus Hierax
241
Battle of the Aegates Islands
240–238
War between Carthage and its mercenaries
240s
Latin renderings of Greek drama and epic poetry in Rome by Livius Andronicus
238
Roman annexation of Sardinia