[PCOL-FIN-01-PT1] ANTIPSYCHOTICS

THIS FLASHCARDS IS ABOUT [PCOL] ANTIPSYCHOTICS - MESOLIMBIC & MESOCORTICAL.

Schizophrenia

Antipsychotics is much related to psychosis or the condition called?

4

How many dopamine pathways are there?

Non-polar

The drugs in the CNS are?

Non-polar drugs

These drugs can penetrate the blood-brain barrier (BBB).

• Brain

• Spinal chord

CNS drugs targets the central tissues like?

Dopamine

This is a monoamine neurotransmitter; has important role in psychotic disorder especially schizophrenia.

• Mesocortical

• Nigrostriatal

• Tuberoinfundibular

• Mesolimbic

What are the (4) Dopaminergic Pathways?

Hint: Me-Ni-Tu-Me

• Mesocortical

• Mesolimbic

Dopaminergic Pathways:

These (2) dopaminergic pathways are said to be involved in the positive & negative symptoms of psychosis.

Hint: M&M

• Nigrostriatal

• Tuberoinfundibular

Dopaminergic Pathways:

These (2) dopaminergic pathways are said to be involved in the adverse effects of psychotic drugs.

Hint: Ni-Tu

• Accumbens

• Amygdala

• Hippocampus

Mesolimbic contains (3) limbic structures. What are they?

Hint: AAH

1. Mesolimbic pathway

2. Mesolimbic system

This (1) dopaminergic pathway is hyperactive in schizophrenia; it cause the increase of activity in the (2)_____ system.

Dopamine

The activity of this neurotransmitter increases the activity of mesolimbic pathway/system.

Positive symptoms

What is the symptom in the mesolimbic pathway?

Positive Symptoms

This symptom abnormally adds up to the normal behavior of a person.

• Hallucinations

• Delusions

• Disorganized speech or thoughts

• Bizarre behaviors

Positive symptoms in mesolimbic pathway includes?

Hint: HD-DB

• Auditory

• Visual

Hallucinations could be auditory, olfactory, and visual but which from the three are the (2) common?

• Paranoia

• False belief

Delusions refers to (2)?

Suicidal

Patients with severe schizophrenia is needed to be monitored because these symptoms (hallucinations, delusions, disorganized speech or thoughts, bizarre behaviors) could manifest and these patients are prone to be?

Mesocortical

This dopaminergic pathway is underactive schizophrenia; decrease activity of dopamine in the system.

Negative/Cognitive Symptoms

What is the symptom in the mesocortical pathway?

Negative/Cognitive Symptoms

This symptom subtracts or take away something from the behavior of the person; decrease in the dopamine activity in the mesocortical system.

Cognitive

This is the conscious intellect activity.

• Abolition

• Flat affect

• Alogia

• Anhedonia

• Asociality

Negative/Cognitive symptoms in mesocortical pathway includes?

Hint: AF-AAA

Loss of motivation

Abolition is defined as the?

Monotonous voice

Flat affect is defined as the?; uniform tune in the voice despite the different emotions.

Poverty of speech

Alogia is defined as the?; the patient doesn’t talk that much.

Inability to feel pleasure

Anhedonia is defined as the?

Social withdrawal or loner

Asociality is defined as the?

Info

Positive Symptoms: Given more proper pharmacologic treatment/approach.

Negative Symptoms: Not pharmacologic treatment/approach.

Positive/Active Symptoms

This symptoms includes thought disturbances, delusions, and hallucinations.

Negative/Passive Symptoms

This symptoms includes social withdrawal, loss of drive, diminished affect, paucity of speech, and impaired personal hygiene.

Info

All antipsychotics treats positive symptoms; decreases the dopamine level by blocking its receptor.