Opioid Analgesics - Pharmacology

Drug List

Strong Analgesics (mu agonists)

Partial Agonists & Mixed Agonsit/Antagonists

Antagonists

Others

Terminology

Routes of administration

Opioid distribution, metabolism and elimination

Opioid Receptors and Analgesia

Biased Signaling via Opioid Receptors

Biased Signaling via Opioid Receptors

Structural activity relationship

Structures of opioid drugs

Opiates vs Semi-synthetic vs Synthetic

Structures of morphine-related opiate agonists and antagonists

Opioid Receptors

Spinal actions of opioids

Dopaminergic reward pathway

Side effects

Opioid-Induced Respiratory Depression

Factors exacerbating opiate-induced respiratory depression

Tolerance

Dependance/Withdrawal

Potent μ-opioid receptor agonists

Potent μ-opioid receptor agonists continued

Potent μ-opioid receptor agonists continued

Potent μ-opioid receptor agonists continued

Opioid antagonists

Opioid antagonists continued

Opioid use disorder

Opioid Overdose

Special Considerations

Management of opioid withdrawal