Multi-Functional Roles of Menstrual Blood-Derived Stem Cells in Regenerative Medicine

These flashcards cover key concepts regarding menstrual blood-derived stem cells (MenSCs) and their significance in regenerative medicine.

Menstrual blood-derived stem cells (MenSCs)

A novel source of mesenchymal stem cells (MSCs) discovered in 2007.

Key advantages of MenSCs

Non-invasive collection processes, high proliferation rate, pluripotency, and low immunogenicity.

Immunophenotype of MenSCs includes positivity for surface markers such as __, __, and __.

CD9, CD29, CD73, CD90, and CD105.

MenSCs have promising therapeutic effects in diseases like __, __, and __.

Liver disease, diabetes, stroke.

MenSCs are harvested from __, providing a less invasive alternative compared to other sources of MSCs.

Menstrual blood.

The differentiation capacity of MenSCs includes the ability to develop into __, __, and __ cell types.

Endothelial, myocytic, hepatocyte-like cells.

Therapeutic effects of MenSCs are attributed to their ability to secrete __ and regulate immune responses.

Soluble factors.

MenSCs have shown potential in treating __ syndrome by increasing endometrial thickness.

Asherman.

Research on MenSCs is still in its infancy, particularly regarding their __ properties and mechanisms.

Immunomodulatory.

MenSCs could improve functions in __ cancer by enhancing the ovarian microenvironment.

Ovarian.

In Alzheimer's disease models, MenSCs significantly improved and in transgenic mice.

Memory ability, spatial learning characteristics.

Significant concerns regarding the long-term safety of MenSCs arise due to a lack of __ markers to monitor them in the body.

Specific.

MenSCs have been extensively studied in __ trials compared to other sources of MSCs.

Preclinical.

MenSCs derived exosomes have been proven to improve liver function in cases of __ failure.

Fulminant.

The standard for isolating MenSCs should comply with good manufacturing practice (GMP) to ensure __.

Safety and quality.

The study of MenSCs offers potential solutions for __ therapies in treating various diseases through advanced regenerative medicine.

Cellular.