Ion Flux Across Cell Membranes

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Last updated 2:29 AM on 9/12/26
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5 Terms

1
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Brugada syndrome

Caused by mutations to SCN5A gene

encodes for sodium channel unit

autosomal dominant

sudden unexplained nocturnal death syndrome

2
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Shark fin ECG finding indicates

Brugada syndrome

3
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Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is caused by

mutation of RyR2 gene

codes for protein called ryanodine receptor 2

  • makes calcium transporting channels in SR

    • cause contraction


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CPVT causes

very fast ventricular rhythm (caused by leaky calcium channels in muscles cells

5
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Glycosides (digitoxin)

Inhibit sodium-potassium pump in cardiac cells

  • less Na gradient to do work, more calcium inside cell

  • Excess calcium is stored in ER for contraction (increases force of contraction)

  • positive ionotropic effect → stronger muscle contraction