Integration of metabolic pathways

FNN200

Energy homeostasis in the cell

• cell balance of energy production and expenditure to maintain intemal energy balance 

• it is essential for the survival and optimal functioning of cells 

• depends on which wa ymolecules flow 

Catabolic processes

• glycolysis

• glycogenolysis

• Cori cycle - lactate production

• Krebs cycle / TCA cycle 

• electron transport chain 

• Lipolysis

• ketogenesis 

  • break down FA only genesis that is catabolic

• Ketolysis 

Anabolic processes

• glycogenesis

• gluconeogenesis

• lipogenesis

2 criticalpoints for macronutrient metabolism

• cytosol

  • Pryuvate

  • Can go in many directions depending on energy state and is required for Krebs

• Mitochondria

  • Acetyl-CoA

  • common intermediate across all 3 macronutrients

  • Pyruvate → acetyl-CoA is irreversible

Regulatory enzymes

• strategic points 

• more unidirectional (irriversible)

• responsive to cellular signals 

• controlled allosterically

Compartmentalization 

• eg. bringing things into the mitochondria

Ways that homeostasis is achieved and maintained

• regulatory enzymes

• compartmentalization