Unit 10: Soluble Immune Response Mediators immuno

This collection of flashcards focuses on key concepts related to soluble immune response mediators from Unit 10 of the immunology lecture notes.

What are Biological Response Modifiers (BRMs)?

Substances such as cytokines secreted by immune cells that modify immune responses.

What are cytokines?

Polypeptide products of activated cells that regulate immune response.

What is the main role of Interleukins (ILs)?

They mediate interactions between leukocytes and modulate inflammation and immune responses.

Where are Acute-Phase Reactants synthesized?

In the liver.

What is the function of Tumor Necrosis Factor (TNF)?

It recruits neutrophils and monocytes to infection sites and mediates acute inflammatory response.

What are chemokines often referred to as?

Traffic cops.

What is a cytokine storm?

Severe damage as the immune system attacks self cells and tissues in addition to invaders.

What do Interferons (IFNs) do?

They provide a natural defense against viral infection and activate immune cells.

What can excessive amounts of TNF lead to?

Septic shock, a life-threatening complication of severe infections.

List one role of Acute-Phase Reactants in clinical settings.

They are utilized to monitor disease progress and assess therapy effectiveness.