TERATOGENS

phocomelia

thalidomide

fetal warfarin syndrome

warfarin

hypoplastic nose, frontal bossing, syndactyly

fetal warfarin syndrome

bone abnormalities, enamel hypoplasia

tetracycline

what can be given to pregnant px for prophylaxis of leptospirosis (originally, doxycycline which is a tetracycline)

azithromycin

ebstein’s anomaly/displaced triscuspid valve

lithium

aplasia cutis

methimazole

in what specific trimester methimazole cannot be given

first trimester

why the first trimester? (methimazole)

it is when skin formation happens

alternative for methimazole for pregnant px during first trimester

propylthiouracil (ptu)

neural tube defects:spina bifida

carbamzepine, valproic acid

prevention of spina bifida during first trimester

folic acid

cancer of the vagina, cervix (female) & infertility (male)

diethylstilbestrol

fetal hydantoin syndrome

phenytoin

microcephaly, upturned nose, cleft lip and palate

fetal hydantoin syndrome

renal dysgenesis

ACEI/ARBS

fetal alcohol syndrom

alcohol

low IQ, smooth philtrum, clinodactyly

fetal alcohol syndrome