Pyruvate Oxidation and The Krebs Cycle

pyruvate (3C) —>

acetyl CoA by redox, decarboxylation, add one CoA

acetyl CoA (2c)—>

citrate (6c) by synthesis with oxaloacetate (4C), hydration

citrate (6c) —>

isocitrate (6c) by isomerization

isocitrate —>

a-ketogluterate (5C) by redox, decarboxylation

a-ketogluterate (5C)—>

succinyl coA (4C) by redox, decarboxylation, addition of coA

succinyl coA (4C) —>

succinate (4C) by phosphorylation, removal of coA

succinate (4C) —>

fumerate (4C) by redox

fumerate (4C) —>

malate (4C) by hydration

malate (4C) —>

oxaloacetate (4C) by redox

how many CO2 produced per turn

2

NADH produced per turn

3

FADH produced per turn

1

GTP produced per turn

1

CoA produced per turn

1

total ATP produced per turn

11

where in the cell does krebs take place

mitochondrial matric

what reaction forms isocitrate from citrate

isomerization

what molecule does acetyl-coA bond with at the start of krebs

oxaloacetate

what happens to the carbon atom between citrate and a-ketogluterate

decarboxylation, released as CO2

what molecule in the krebs cycle has the highest potential energy

citrate, most C molecules, energy has not been released as NADH, FADH, or ATP

what molecule in the krebs cycle has the lowest potential energy

oxaloacetate, least C molecules, energy released as ATP, NADH, Fadh

what occurs when GTP is used to make ATP

phosphorylation of GTP, phosphate from GTP transferred to ADP to produce ATP

NAD+ —> NADH

redox reaction

why is there more than one turn of the krebs cycle for every glucose molecule

each glucose produces 2 pyruvate

use of coA in pyruvate oxidation and krebs

brings substrate to correct position

products of cellular respiration produced directly from krebs

6CO2

use of oxygen

oxygen needed to make CO2 in link reaction and krebs