Pyruvate Oxidation and The Krebs Cycle

Pyruvate Oxidation

  1. pyruvate converted to acetyl CoA

    1. redox (NAD+ —> NADH)

    2. decarboxylation

Krebs Cycle

  1. acetyl CoA combines with oxaloacetate and H2O to create citrate

    1. hydration

  2. citrate converted to isocitrate

    1. isomerization

  3. isocitrate converted to a-ketogluterate

    1. redox (NAD+ —> NADH)

    2. decarboxylation

  4. a-ketogluterate converted to succinyl coA

    1. redox (NAD+ —> NADH)

    2. decarboxylation

    3. CoA added

  5. succinyl CoA converted to succinate

    1. substrate level phosphorylation (GDP —> GTP)

    2. CoA removed

  6. succinate converted to fumerate

    1. redox (FAD —> FADH2)

  7. fumerate converted to malate

    1. hydration

  8. malate converted to oxaloacetate

    1. redox (NAD+ —> NADH)