Top 300 Quiz 6

ABATACEPT

generic

Orencia

ABATACEPT

Dosage Forms

Prefilled Syringes

Solution Autoinjector

Solution Reconstituted

ABATACEPT

Prefilled Syringes

50 mg/0.4 mL

87.5 mg/0.7 mL

125 mg/1 mL

ABATACEPT

Solution Autoinjector

125 mg/1 mL

ABATACEPT

Solution Reconstituted

250 mg

ABATACEPT

Common FDA Label Indication, Dosing, and Titration

Rheumatoid arthritis (RA)

Juvenile idiopathic arthritis

Prophylaxis of acute GVHD in those undergoing HSCT

ABATACEPT

MOA

recombinant fusion protein → T-cell activation→ interrupting interaction CD28 on the T cell and CD80/CD86

ABATACEPT

Adverse Reactions

nasopharyngitis

upper respiratory tract infection

CMV reactivation

epistaxis

anemia

hypermagnesemia

Anaphylaxis

COPD exacerbation

reactivation of latent infections

ABATACEPT

Key Patient Counseling Points

Store in refrigerator

Protect from light

Follow injection instructions. Rotate injection sites

Notify HCP for signs of infection or trouble breathing

ADALIMUMAB

generic

Humira

Abrilada

Amjevita

Cyltezo

Hadlima

Hulio

Hyrimoz

Simlandi

Yuflyma

Yusimry

ADALIMUMAB

Dosage Forms

Single Dose Vial

Prefilled Syringe

Auto-injector Pen

ADALIMUMAB

Single Dose Vial

40 mg/0.8 mL

ADALIMUMAB

Prefilled Syringe

10 mg/0.1 mL, 10 mg/0.2 mL

20 mg/0.2 mL, 20 mg/0.4 mL

40 mg/0.4 mL, 40 mg/0.8 mL

80 mg/0.8 mL

ADALIMUMAB

Auto-injector Pen

40 mg/0.4 mL,

40 mg/0.8 mL

80 mg/0.8 mL

ADALIMUMAB

Common FDA Label Indication, Dosing, and Titration

Ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis

Crohn disease

Hidradenitis suppurativa

Juvenile idiopathic arthritis

Plaque psoriasis

Ulcerative colitis

Uveitis

ADALIMUMAB

MOA

Recombinant monoclonal antibody that binds to soluble tumor necrosis factor (TNF) alpha with p55 and p75 cell surface TNF receptors

ADALIMUMAB

Box Warnings

Malignancy

serious infections

ADALIMUMAB

Adverse Reactions

Antibody development

injection site reactions

Acute liver failure

CNS demyelinating disease

lupus-like syndrome, pancytopenia, psoriasis

reactivation of latent infections

ADALIMUMAB

Key Patient Counseling Points

Store in refrigerator

stored at room temperature for up to 14 d

Ensure vaccinations are current prior to starting therapy

METHYLPREDNISOLONE SODIUM SUCCINATE

generic

SOLU-Medrol

METHYLPREDNISOLONE SODIUM SUCCINATE

Dosage Forms

Single-Dose Vial, with Benzyl Alcohol

Single-Dose Vial, Preservative Free

Multiple-Dose Vial, with Benzyl Alcohol

METHYLPREDNISOLONE SODIUM SUCCINATE

Single-Dose Vial, with Benzyl Alcohol

40 mg, 125 mg

METHYLPREDNISOLONE SODIUM SUCCINATE

Single-Dose Vial, Preservative Free

40 mg/1 mL

125 mg/2 mL

500 mg/4 mL

1000 mg/8 mL

METHYLPREDNISOLONE SODIUM SUCCINATE

Multiple-Dose Vial, with Benzyl Alcohol

500 mg, 1 g, 2 g

METHYLPREDNISOLONE SODIUM SUCCINATE

Common FDA Label Indication, Dosing, and Titration

Inflammatory and allergic states of the skin, eyes, gastrointestinal tract, endocrine system, lungs, kidneys, musculoskeletal system, immune system, blood and central nervous system

palliative treatment in neoplastic diseases and for nephrotic syndrome

METHYLPREDNISOLONE SODIUM SUCCINATE

MOA

Adrenal Corticosteroid

METHYLPREDNISOLONE SODIUM SUCCINATE

Contraindications

Systemic fungal infections

intrathecal administration

IM route for idiopathic thrombocytopenic purpura

benzyl alcohol use in neonates

allergy to cow’s milk

administration of live vaccines

METHYLPREDNISOLONE SODIUM SUCCINATE

Adverse Reactions

GI upset

hyperglycemia

Acute hepatitis

Cushing syndrome

decreased growth in children

heart wall rupture

primary adrenocortical insufficiency

METHYLPREDNISOLONE SODIUM SUCCINATE

Key Patient Counseling Points

For high-dose or longer-term treatment, inform patients to monitor for signs of hyperglycemia, osteoporosis, adrenocortical insufficiency, and infection

GEMCITABINE

Dosage Forms

Intravenous Solution

Powder for Solution

GEMCITABINE

Powder for Solution

200 mg, 1 g, 2 g

GEMCITABINE

Intravenous Solution

200 mg/5.26 mL, 200 mg/2 mL

1 g/10 mL, 1 g/26.3 mL

1.5 g/15 mL

2 g/20 mL, 2 g/52.6 mL

GEMCITABINE

Common FDA Label Indication, Dosing, and Titration

Non–small-cell lung cancer

Breast cancer,

Ovarian cancer

Pancreatic cancer

GEMCITABINE

MOA

pyrim blocks synthesis through inhibition of ribonucleotide reductase

incorporates into DNA to prevent the replication process of DNA polymerase

GEMCITABINE

Adverse Reactions

Alopecia

flu-like symptoms, hyperglycemia, hypomagnesemia

myelosuppression

peripheral edema

pyrexia

capillary leak syndrome

febrile neutropenia

hemolytic uremic syndrome

renal failure

GEMCITABINE

Key Patient Counseling Points

Thrombocytopenia and fatigue are dose-limiting toxicities

Counsel S/S bleeding

Flu-like symptoms often present 24-48 h → resolve with acetaminophen administration

Contact HCP if there are any changes in color or volume of urine or increased bleeding or bruising

TRIAMCINOLONE NASAL

generic

Nasacort Allergy 24HR

TRIAMCINOLONE NASAL

Dosage Forms

Nasal Spray

TRIAMCINOLONE NASAL

Nasal Spray

55 mcg/actuation

TRIAMCINOLONE NASAL

Common Self-Care Indications, Titration, and Dosing

Perennial or seasonal allergic rhinitis

TRIAMCINOLONE NASAL

MOA

phospholipase A2-inhibitory proteins

TRIAMCINOLONE NASAL

Adverse Reactions

Nasal irritation and burning

pharyngitis

glaucoma

secondary hypocortisolism

Osteoporosis

TRIAMCINOLONE NASAL

Key Patient Counseling Points

Children ≤12 y of age supervised

bottle must be primed and shaken 1st time use, if it has not been used in >14 d

Patients should clear nasal passages by blowing nose prior to use

“nose to the toes” technique of tilting the head slightly downward

Aiming the spray away from the nasal septum toward the ears slightly inserted into the nostril can help minimize irritation and nosebleeds

Medication may take 7 d to take full effect

Do not blow the nose for at least 15 min after use

Nozzle only can be cleaned with tap water