Type III hypersensitivity reactions & Serum sickness and Arthus reaction

What factors influence whether immune complexes drive Type III hypersensitivity?

Factors include the affinity of a particular antigen to a specific location or tissue, disruption of normal phagocytosis, and the chemical nature of the antigen, which affects how efficiently phagocytic cells can engulf it.

What is serum sickness?

Is a Type III hypersensitivity reaction, first diagnosed after the use of horse serum to treat diphtheria in the early 20th century.

It is now a concern due to the use of mouse monoclonal antibodies in immunotherapy.

What is an Arthus reaction?

Occurs four to ten hours after exposure to an antigen and happens when immune complexes form and large amounts of antigen are deposited

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