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major depressive disorder
period of two weeks or longer in which symptoms of depression persist nearly everyday and represent a marked change in pervious functioning
bipolar disorder
indicated by one or more manic episodes usually preceded or followed by episodes of depression
manic episode
period of abnormally and persistently elevated or expansive mood continuing for a least one week
heritability of bipolar
largest genetic contributions of any psychological disorder
circadian rhythms
life stressors disrupting zeitgebers regulating natural circadian rhythms
zeitgebers
biological clock for rest
engagement dysregulation
dysfunction of neurobiological systems influencing reward/goals directed behavior
kindling hypotheses
initial episodes decrease threshold for subsequent episodes, resulting in more frequent and severe mania