Opioids/Pain Meds Test Questions

Breastfeeding and pregnancy

Can cause respiratory issues

What are pure agonist opioids contraindicated with?

Naloxone (narcan)

What is the only opioid pure-antagonist?

Give repeat doses

What do you do if Naloxone does not work the first time?

Withdrawal symptoms

What should you expect after administering Naloxone?

Reverses effects of pure-agonist opioids

What does Naloxone do?

4 grams/day for 10 days

What is the max does of acetaminophen?

Protects gastric mucosa, supports renal function, promotes platelet aggregation.

What does a COX-1 inhibitor do?

Sensitizes receptors and enables inflammation sites

Mediates fever and pain perception

What does a COX-2 inhibitor do?

Inhibit COX-1 and COX-2

What do the first generation NSAIDs do?

Only inhibits COX-2

What does the second generation NSAID do? (celecoxib)

They activate the Mu and Kappa receptors

How do pure opioid agonists work?

Mu

Kappa

Delta

What are the 3 main classes of opioid receptors?

Analgesia, respiratory depression, euphoria, sedation, physical dependence

What does the Mu receptor effect?

Analgesia and sedation (psychomimetic effects)

What does the Kappa receptor effect?

Analgesia and gastric motility

What does the Delta receptor effect?

It metabolizes into Normeperidine

Long half-lifel no analgesia, hepatic/renal toxicity, seizures

What is unique about demerol?

To a newborn who’s mother received opioids

When are opioid agonist-antagonists often given?

Aspirin

What is an example of an ASA? (Acetylsalicylic Acid)

N-Acetylcysteine (Mucomyst)

What do you use to neutralize acetaminophen?

Bleeding, tinnitus

What are some adverse affects of ASA?

cardiovascular issues

What do NSAIDs increase the risk of?

Holds Na+, releases K+

What affects do glucocorticoids have on electrolytes?