Innate Immune Response

when is the innate immune system introduced

birth

what is the result of a non-specific response

acute inflammation

what type of response is acute inflammation

vascular response

what is involved with a non-specific defense system

neutrophils, complement system, phagocytosis, and fever

what is the most numerous WBC

neutrophils (PMN)

what cells in the innate immune response are considered 1st line defenders

neutrophils

what type of cell are neutrophils

phagocytes

when there is an issue with neutrophils, what results

periodontal disease

what are the 3 main functions of macrophages

phagocytosis, cytokine production, and transport, process, and present antigens

WBC that destroy tumor cells and virally infected cells

natural killer cell

what type of cell are natural killer cells

non-specific killers

how are natural killer cells activated

without an antibody or prior antigen exposure

common at sites of external exposure and close to blood vessels

mast cells

how do mast cells function

degranulation

what is the process of mast cells functioning

release histamine, capillaries dilate, and edema results

20+ proteins in blood that assist other defense mechanisms

complement system

what immunoglobulins can activate the complement system

IgG and IgM

once the cell is infected with the virus, what does the host cell secrete

interferons

what do interferons stimulate healthy cells to make

proteins