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What are the 2 main types of diarrhea based on mechanism
Secretory Diarrhea
Osmotic Diarrhea
What causes secretory diarrhea?
Increased secretion of water
What causes osmotic diarrhea?
Increased osmotically active solutes (maldigestion and malabsorption)
What are the characteristics of diarrhea?
Watery
Normal odor
Increase fecal frequency and volume
What are the characteristics of steatorrhea?
Greasy
Foul odor
Spongy consistency
This indicates water and electrolyte imbalance, acidosis and weight loss
Diarrhea
This indicates malnutrition and weight loss
Steatorrhea
What is the cause of steatorrhea?
Maldigestion or Malabsorption of dietary fats
What is the daily fecal passage in grams?
100 to 200 grams
What test indicates malabsoprtion?
D-xylose test
What condition involves altered intestinal motility and may cause diarrhea or constipation
Irritable Bowel Syndrome (IBS)
What is intestinal hypermotility associated with?
Diarrhea
What does the presence of WBCs of feces indicate?
Inflammation or Mucosal damage
What do undigested striated muscle fibers in feces suggest?
Maldigestion
What are the two types of muscle fiber striations seen in feces?
Vertical and Horizontal striations
What is the significance of neutrophils in fecal leukocytes?
Wet prep with methylene blue
Dried smears with wright’s or gram stain
What is the gold standard method for fecal fat quantification?
Van de kramer titration
What is the most frequent test for occult blood in stool?
Guaiac-based test
What principle does the guaiac test rely on?
Pseudoperoxidase activity of hemoglobin
What specimen is used for APT test
Grossly bloody stools
Vomitus of the baby
What does the APT test differentiate?
Fetal blood vs Maternal blood
What reagent is added in the APT test to determine blood origin?
Sodium hydroxide