Skills lab 3 top 200

Amoxicillin brand names

Amoxil, Moxatag, Trimox

Amoxicillin main indication

Antibiotic

Amoxicillin therapeutic class

B-lactam antibiotic

Amoxicillin FDA-labeled indications

• Acute otitis media

• Lower respiratory tract infection

• Streptococcal pharyngitis

• H. pylori

• Infections of ear, nose, throat, skin, genitourinary system

Amoxicillin dosage forms

Capsule, tablet, chewable tablet, suspension

Amoxicillin MOA

inhibits the biosynthesis of bacterial cell wall mucopeptide

Amoxicillin box warnings

none

Amoxicillin common ADRs

Diarrhea, nausea

Amoxicillin counseling points

• Complete full course of therapy

• For suspension, shake well and refrigerate

• Can take with food to avoid upset stomach.

• Do not mix suspension w/ food or beverages and use with measuring device that comes with prescription.

• Symptoms should improve within 2 -3 days, seek HCP is it worsens

• May decrease effectiveness of oral contraceptives

Amoxicillin/clavulanate potassium brand name

Augmentin

Amox/clav main indication

Antibiotic

Amox/clav therapeutic class

B-lactam antibiotic

Amox/clav FDA-labeled indications

• Acute otitis media

• Community-acquired pneumonia

• Lower respiratory tract infection

• Infections of sinuses, skin, genitourinary system

• UTI: acute cystitis + pyelonephritis

Amox/clav MOA

Bacterial cell wall synthesis inhibitor + B-lactamase inhibitor

Amox/clav box warnings

none

Amox/clav ADRs

Nausea, diarrhea

Amox/clav counseling points

• Complete full course of therapy

• For suspension, shake well and refrigerate. Good for 10 days.

• Can take with food to avoid upset stomach.

• Do not mix suspension w/ food or beverages.

• Symptoms should improve within 2 -3 days, seek HCP is it worsens

• May decrease effectiveness of oral contraceptives

Azithromycin brand names

Zithromax

Azithromycin main indication

antibiotic

Azithromycin therapeutic class

macrolide antibiotic

Azithromycin FDA-labeled indications

• Acute infective exacerbation of COPD

• Skin or tissue infection

• Bacterial sinusitis

• Chancroid

• Nongonococcal cervicitis and urethritis

• CAP

• STIs

• Streptococcal pharyngitis

Azithromycin MOA

Binds to the 50S ribosomal subunit, thus interfering w/ microbial protein synthesis

Azithromycin box warnings

none

Azithromycin ADRs

Diarrhea, n/v

Azithromycin counseling points

• Complete full course

• Tablets be taken with or without food, but some pts report increased tolerance with food.

• Do not mix suspension w/ food or beverages, but food can be taken afterward

• Symptoms should improve within 2 -3 days, seek HCP is it worsens

Cefdinir brand name

Omnicef

Cefdinir main indication

antibiotic

Cefdinir therapeutic class

3rd-gen cephalosporin

Cefdinir FDA-labeled indications

• Acute OM

• Pharyngitis

• Tonsillitis

• Bronchitis

• Uncomplicated skin and/or SQ tissue infection

• CAP

• COPD, acute exacerbation

• Streptococcal pharyngitis, group A (alternative agent for mild, non-anaphylactic penicillin allergic)

Cefdinir dosage forms

capsule, suspension

Cefdinir MOA

inhibits bacterial cell wall synthesis

Cefdinir box warnings

none

Cefdinir ADR

diarrhea

Cefdinir counseling points

• Complete full course

• For suspension, shake well and can be stored at room temp; Good for 10 days.

• Do not mix suspension w/ food or beverages, but food can be taken afterward.

• Symptoms should improve within 2 -3 days, seek HCP is it worsens

• Separate administration of antacids, iron and vitamins by 2h

Cephalexin brand name

Keflex

Cephalexin main indicatoin

1st-gen cephalosporin

Cephalexin FDA labeled indications

• Infection of skin, respiratory tract, UTI

• Osteomyelitis

• OM

• Streptococcal pharyngitis

• Impetigo (skin infection)

• Ecthyma (deep impetigo)

• Cellulitis (nonpurulent)

• Erysipelas

Cephalexin MOA

inhibits bacterial cell wall synthesis

Cephalexin box warnings

none

Cephalexin ADR

nausea

Cephalexin counseling points

• Seek medical attention if rash develops

• Complete full course

• For suspension, shake well and refrigerate; has short expiration date

• Do not mix suspension w/ food or beverages, but food can be taken afterward.

• Symptoms should improve within 2 -3 days, seek HCP is it worsens

Ciprofloxacin brand name

Cipro

Ciprofloxacin main indication

antibiotic

Ciprofloxacin therapeutic class

Fluoroquinolone

Ciprofloxacin FDA-labeled indications

• Anthrax

• Bacterial prostatitis, chronic

• Bronchitis

• Infection of bone, skin, or soft tissue, abdomen, sinusitis, Lower respiratory tract

• UTI

Ciprofloxacin dosage form

tablet, suspension

Ciprofloxacin MOA

Inhibits bacterial DNA gyrase and topoisomerase IV

Ciprofloxacin box warnings

• Contraindicated in pregnancy

• Tendon rupture

• peripheral neuropathy

• myasthenia gravis exacerbation

• aortic aneurysm

Ciprofloxacin ADRs

tooth discoloration, musculoskeletal signs/symptoms

Ciprofloxacin counseling points

• Take with or without food, but not with milk or other dairy products.

• Take cipro at least 2h before or 6h after antacids, sucralfate or mineral supplements and multivitamins with calcium, iron or zinc.

• If using suspension, shake well and can be stored at room temp