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Ectoderm
Which germ layer gives rise to the CNS and PNS?
Ectoderm
Which germ layer gives rise to the epidermis?
Ectoderm
Which germ layer gives rise to nails and hair?
Ectoderm
Which germ layer gives rise to sensory epithelium of the ears, nose and eyes?
Ectoderm
Which germ layer gives rise to sweat, sebaceous, lacrimal and mammary glands?
Ectoderm
Which germ layer gives rise to tooth enamel?
Ectoderm
Which germ layer gives rise to the pituitary gland?
Ectoderm
Which germ layer gives rise to the external auditory meatus?
Between 3rd and 4th week
When does neurulation occur?
Formation of the neural tube
What is neurulation?
Ectoderm
What germ layer does neurulation take place?
Brain and spinal cord (CNS)
Which does the neural tube give rise to?
Dorsal aspect of the neural tube
Where are neural crest cells located?
Ventrally into underlying mesoderm
Where do neural crest cells migrate to?
Majority of PNS structures
(Noteable: Septum of heart, dorsal root ganglia, bones/dermis of face)
What do neural crest cells give rise to?
Paraxial mesoderm
The mesoderm initially thickens along the midline of the embryo to form what?
Lateral plate mesoderm
Laterally the mesoderm remains thin to form what?
Somatic (parietal) and splanchnic (visceral) mesoderm
The lateral place mesoderm divides into what two layers?
Intermediate mesoderm
What is located between the paraxial mesoderm and the lateral plate mesoderm?
Paraxial mesoderm
(located on either side of notochord)
Which part of the mesoderm would be labelled in the orange box?

Intermediate mesoderm
Which part of the mesoderm would be labelled in the orange box?

Somites
At the third week, paraxial mesoderm begins to organize into ball like segments called what?
Formation of axial skeleton
What is the function of somites?
Paraxial mesoderm
Which part of the mesoderm are somites found?
Occipital region
The first pair of somites arise in what region of the embryo?
False
(Cranial to caudal)
True or False: Somite development progresses caudal to cranial.
42-44
At the end of the fifth week, how many pairs of somites are present?
4
How many pairs of somites are present in the occipital region?
8
(same as # of cervical nerves)
How many pairs of somites are present in the cervical region?
12
(same as # of thoracic nerves)
How many pairs of somites are present in the thoracic region?
5
(same as # of lumbar nerves)
How many pairs of somites are present in the lumbar region?
5
(same as # of sacral nerves)
How many pairs of somites are present in the sacral region?
8-10
How many somites are present in the coccygeal region?
1st occipital somite and some coccygeal somites
Which somites regress?
Axial skeleton
The rest of the somites form what?
Epithelization
Somites undergo what to form a donut like structure?
Sclerotome
Ventral and medial somitic cell sbecome mesenchyme to form what? (Labelled by blue box)

Dermatome
Cells between dorsomedial and ventrolateral somitic cells form what? (Labelled by gray box)

Muscle cells
Cells at dorsomedial and ventrolateral edges of somites form precursors for what cells?
Myotome
Cells will become mesenchymal and migrate beneath dermatome and form what? (Labelled by yellow box)

Vertebrae and ribs
(sclera=bone)
What does the sclerotome give rise to?
Dermis of dorsal body region
(derma=skin)
What does the dermatome give rise to?
Trunk and limb musculature
(myo=muscle)
What does the myotome give rise to?
Urogenital structures
(kidneys, ureter, female/male reproductive anatomy)
The intermediate mesoderm gives rise to which structures?
Somatic (parietal) layer and splanchnic (visceral) layer
The lateral plate mesoderm splits into what two layers?
Amniotic cavity
Which cavity is lined by the somatic/parietal lateral plate mesoderm?
Yolk sac
Which cavity is lined by the splanchnic/visceral lateral plate mesoderm?
Somatic
(think outside)
Does the somatic or splanchnic lateral plate mesoderm give rise to the dermis of the ventral body region?
Somatic
Does the somatic or splanchnic lateral plate mesoderm give rise to bones and ligaments?
Somatic (parietal)
Does the somatic or splanchnic lateral plate mesoderm give rise to parietal serosa?
Splanchnic
Does the somatic or splanchnic lateral plate mesoderm give rise to walls of the digestive and respiratory tracts?
Splanchnic
Does the somatic or splanchnic lateral plate mesoderm give rise to the heart and blood vessels?
Splanchnic (visceral)
Does the somatic or splanchnic lateral plate mesoderm give rise to visceral serosa?
Paraxial mesoderm
What is labeled 1?

Amniotic cavity
What is labeled 2?

Intermediate mesoderm
What is labeled 3?

Somatic lateral plate mesoderm
What is labeled 4?

Splanchnic lateral plate mesoderm
What is labeled 5?

Yolk sac
What is labeled 6?

Ectoderm and somatic mesoderm
Which germ layers form the lateral body wall?
Splanchnic mesoderm and endoderm
Which germ layers form the wall of the gut tube?
Somatic and splanchnic mesoderm layers
The intraembryonic cavity is located between what two layers?
Abdominal cavity
What does the intraembryonic cavity give rise to eventually?
Vasculogenesis
Blood vessels arise from blood islands
Angiogenesis
New blood vessels sprout from existing vessels
Splanchnic lateral plate mesoderm
Blood cells and vessels arise from what layer?
Wall of yolk sac
The first blood cells arise in blood islands surrounding what structure?
Mesoderm surrounding the aorta
The definitive hematopoietic stem cells are derived from what?
Liver
The definitive hematopoietic stem cells colonize what organ?
Liver
What is the major hematopoietic organ of an embryo?
Bone marrow
Stem cells from the liver colonize what?
Blood forming function
Stem cells from the liver colonize the bone marrow and the liver loses what function?
7th month
During what month of gestation does the liver lose its blood forming function?
True (later becomes nucleus pulposus)
True or False: The notochord is only present during early embryonic development.
Nucleus pulposus
What structure is remnant of the notochord?
Nucleus pulposus
What structure is labelled?

Endoderm
Which germ layer gives rise to epithelial linings?
Endoderm
Which germ layer gives rise to the parenchyma of the thyroid, parathyroid, liver and pancreas?
Primitive streak
What establishes the body axes of the embryo?
True
True or False: Body folding occurs simultaneously in sagittal and lateral planes.
Ventral body wall
During neurulation (week 3), right and left sides of the embryonic disc flex and move ventrally to close what?
Vitelline duct
What term describes the remaining connection between the midgut and yolk sac during lateral body folding?

Ventral body wall and primitive body cavity
Lateral body wall folds meet in midline forming what?
Primitive gut tube
The splanchnic mesoderm and endoderm form what during lateral body folding?
Vitelline duct
What is labelled 1?

Primitive gut cavity
What is labelled 2?

The development of the brain
(increased weight causes cranial end to curve ventrally)
What causes cranial folding?
Oropharyngeal membrane
Which structure acts as a hinge during cranial body folding to correctly orient the brain, mouth, heart, and diaphragm?

Mouth
What does the oropharyngeal membrane give rise to?
Diaphragm and connective tissue of liver
What does the septum transversum give rise to?
Septum transversum
Which structure separates the primitive thoracic and abdominal cavities?
Growth of the distal neural tube
What causes caudal folding?
Cloacal membrane
Which structure swings ventrally during caudal body folding to correctly orient the umbilical cord/connecting stalk, urogenital, and anal openings?

Connecting stalk
What becomes the future umbilical cord is now attached to the ventral aspect of embryo?
Septum transversum
Block of splanchnic mesoderm that forms connective tissue of liver and central tendon of diaphragm
Primitive thoracic and abdominal
The septum transversum separates what cavities?
Pleuropericardial folds
Which structure expands to form a definitive wall between the thorax and pleuropericardial membranes?
Pleuropericardial membranes
Which structure forms definitive pleural and pericardial cavities?
Pleuropericardial membranes
Which structure contains the phrenic nerve?
Pericardioperitoneal canals
What structure connects the pleural cavities to the peritoneal cavity by travelling through the septum transversum?