Applied Pharmacokinetics: Bayesian and Regression Methods

Flashcards covering pharmacokinetic parameter estimation using regression and Bayesian analysis based on the lecture notes by Reza Mehvar, Ph.D.

What is the first step involved in the individualization of a dosage regimen?

Design of initial dosage regimen

What is the second step involved in the individualization of a dosage regimen?

Estimation of patient-specific pharmacokinetic parameters

What is the third step involved in the individualization of a dosage regimen?

Adjustment of dosage regimen

What are the two primary methods used to calculate patient-specific kinetic parameters from plasma samples?

Regression analysis or Bayesian analysis

If measured plasma concentrations agree with population-predicted values, what action is necessary?

No dosage adjustment is necessary.

What should be done if measured plasma concentrations are 'inappropriate'?

Patient-specific kinetic parameters

What is 'population error' or variability in pharmacokinetics?

Inter-subject variability

What are the two identified causes of random (observation) error?

Errors in the analytical method and Assumptions of the kinetic model

When is nonlinear regression required in pharmacokinetics?

Relationship between variables is nonlinear

What is it called when The process of repeatedly changing kinetic values slightly and recalculating the estimated plasma concentrations until the sum of squares is no longer reduced?

iteration

What is the 'middle-of-the-road' approach that uses both population and individual patient data?

Bayesian analysis

How many samples are at minimum required for regression methods to estimate patient-specific parameters?

At least two samples

Which method is generally superior when measurement error is present (as is always the case in practice)?

Bayesian method