Allele and Gene interactions

Incomplete dominance

Heterozygote has neither the recessive or dominant phenotype, they show a unique mix.

Complementation Test

Test mutants on same gene or different genes

• must be recessive to WT

• True breed parents

Mendelian inheritance

Meiosis and independent assortment

Codominance

Lethal alleles

Temp sensitive alleles/ conditional

At restrictive temperature the protein to activate WT is inactive. At permissive temperatures, the protein is active.

Hierarchy of dominance

Haploinsufficient

Haplosufficient

One allele of the gene is enough to get the Phenotype

Gain of function

Inc gene expression or new function

Loss of function

Null allele

Complementary gene action

Epistasis

Two genes interact to get the same trait, but one is more powerful or hides the visible output, or phenotype of another gene