Peripheral N disorders

Prognosis of Neuropraxia

Positive with removal of compression

Where do we see axonotmesis?

With crush or traction injuries

Tell me about Axonal regeneration

Axons that regenerate do NOT re-myelinated to preinjury level = impacts NCV, speed/coordination of mvmt

Tell me about collateral sprouting

Intact axons can pick up the slack for injured ones and re-innervate denervated muscles. This changes muscle types from type 1 to type 2

Tell me the difference of these terms:

Mononeuropathy

Mononeuropathy multiplex

Radiculopathy

Plexopathy

Mononeuropathy: Involves one nerve (think carpal tunnel syndrome)

Mononeuropathy multiplex: Involves ≥2 nerves without indication of polyneuropathy (think of someone with CTS and cubital tunnel)

Radiculopathy: Involves nerve roots

Plexopathy: Involves plexus

What is segmental demyelination and what is an example

Disease that mainly impacts myelin like GBS(?)

What is axonal degeneration and what is an example

Disease that impacts axons, seen from distal to proximal like neuropathy secondary to alcohol abuse.

Tell me about polyneuropathic conditions

Effects both axon and myelin, think diabetic polyneuropathy

Tell me about the difference between acute / chronic polyneuropathy

Polyneuropathy is more chronic in nature (diabetes), when rapid and acute it is likely due to toxins/poison or autoimmune disorders

Why PT for neuropathy?

Remyelination, axonal regeneration, and collateral sprouting can occur if the causative agent is treated (address early)

What to examine with neuropathy?

Sensory, motor, autonomic changes (hair loss/vascular changes) — These occur in a distal to proximal fashion

Balance/falls (difficulty with static posture and EC)