Reversible Cell Injury Part IV

Hematin

non-iron containing pigment formed by action of acids to hemoglobin—usually artefacts of fixation

negative

Hematin is Perl’s test _____

blood parasitism (malaria), tissue trauma

Pathological form of Hematin are seen in ______ and _____

bilirubin

Breakdown product of hemoglobin

jaundice

Bilirubin visible deposition in tissues

hemolytic jaundice

Bilirubin deposition is tissues results from excessive hemolysis of red blood cells

hepatogenous jaundice

Bilirubin deposition is tissues results from primary liver and gall bladder disease

obstructive jaundice

Bilirubin deposition is tissues results from obstruction of bile ducts

hall’s bilirubin stain

Stain validation of bilirubin

green

On this test, bilirubnin stains what color?

Ferric chloride in trichloroacetic acid (Fouchet’s reagent) + Van Gieson’s stain (counterstain)

hemoglobin metabolism

what the hell is this?

• Lipochrome

• “Wear-and-tear pigment”

• ceroid

• pigment of “brown atrophy”

Lipofuscin is also known as

yellowish brown

pigment of lipofuscin

Lipofuscin

This pathological pigmentation have high lipid content

atrophied, old aged

Lipofuscin pigmentation is often found in the _______ or _____ cells

PAS and Variably acid fast (in carbol fuscin)

Stain of Lipofuscin

melanin

Normal pigment found in the form of fine brown granules in the skin, choroids of the eye, and adrenal medulla

oxidation of the amino acid tyrosine, polymerization

Melanin is produced by melanocytes thru the _______, followed by _____

99.9%

Melanin is an effective absorber of light as it is able to dissipate over ______ of absorbed UV radiation

melanosis

pathological deposition of melanin

Masson-Fontana stain

stain of melanosis

Black

In Masson-Fontana stain, melanin stain what color?

• anthracosis

• silicosis

• asbestosis

• siderosis

Kinds of pneumoconiosis

anthracosis

deposition of black carbon pigment on the lungs (“black lug disease”)

silicosis

deposit of silica (dust)

asbestosis

asbestos bodies

siderosis

deposit of iron

calcification

accumulation of calcium salts in body tissue

• dystrophic calcification

• metastatic calcification

two forms of calcification

dystrophic calcification

form of calcification when there is a prior injury; normal serum calcium