Stage of Lymphoid nodule which is represented as aggregates of smaller B cells with uniform cell density and staining
Primary lymphoid nodules
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Stage of Lymphoid nodule that contain mature but naive B cells
Primary lymphoid organs
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Stage of Lymphoid nodule that does not have germinal center
Primary lymphoid organs
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Stage of Lymphoid nodule that cells are in a resting state
Primary lymphoid organs
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Stage of Lymphoid nodule that show aggregates of large B lymphocytes with more euchromatic cells, seen as the lighter germinal center that represents the active sites of lymphocyte proliferation
Secondary lymphoid nodules
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In secondary lymphoid nodules, this is where B cells proliferate and differentiatte after antigen exposure
Germinal Center
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In secondary lymphoid nodules, this surrounds the germinal center, contains inactive B cells
Mantle Zone
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In secondary lymphoid nodules, this is the outermost layer, contains medium-sized lymphocytes in a reticular framework
Marginal Zone
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Lymph nodes is distribute throughout the body along the ----
lymphatic vessels
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shape of Lymph Nodes
Bean shaped
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Lymph nodes are en---
encapsulated
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Where does the afferent LV enter?
convex surface
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Where does the efferent LV leave?
concave hilum
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Where does the blood vessels and nerve penetrate the organ?
concave hilum
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Filter lymph that defend against the spread of antigens and tumor cells that have invaded the different organ tissues
Lymph Nodes
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Lymphatic vessels coming from the right upper side of the body will drain into the ----------, returning lymph to the bloodstream by the -------
right lymphatic duct subclavian vein
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Lymphatic vessels from the rest of the body, the lower extremities, the left side of the trunk, the arms, and the face will drain lymph into the ------- and it will join the ------------ to bring lymph back to the circulation
Lymph carries ------ and ------ for immune surveillance
antigen-presenting cells (APCs)
antigens
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Lymph node is encapsulate by ---------- extending as ------ within the lymph node parenchyma
dense connective tissue trabeculae
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provides the main structural support for the lymph node and forms the core of lymphatic nodules in the cortex and the medullary cords and sinuses in the medulla
Reticular connective tissue
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region of lymph node where: contains the lymphoid nodules
Cortex
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region of lymph node where: Branches into cortical and trabecular sinuses.
Cortex
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region of lymph node where: Separated from the capsule by the subcapsular sinus.
Cortex
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region of lymph node where: deeper extension of the cortex without lymphoid nodules
Paracortex
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region of lymph node where: T-cell-rich area (main site of antigen presentation).
Paracortex
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region of lymph node where: Contains high endothelial venules (HEVs) → Allows lymphocytes to enter the lymph node from the blood.
Paracortex
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region of lymph node where: has medullary cords and sinuses
Medulla
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region of lymph node where: Innermost region of the lymph node.
Medulla
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Contain B cells, plasma cells, and macrophages.
Medullary cords
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Channels that collect filtered lymph before exiting via efferent lymphatic vessels.
Medullary sinuses
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region of lymph node where: Separated from the connective tissue capsule by the subcapsular sinus, which branches out into cortical and trabecular sinuses
Cortex
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region of lymph node where: presence of lymphoid nodules with or without germinal center
cortex
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Region between cortex and medulla without lymphoid nodules
Paracortex
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region of lymph node where: Contains mostly T lymphocytes (CD3+ T cells).
Paracortex
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Paracortex region contain ______________ which allow lymphocyte to migrate from the blood into the lymph node
high endothelial venules (HEVs)
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In ------------------ the T cell rich pracortex is more prominently stained
immunohistochemical staining
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region of lymph node where it is light staining
Medulla
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Two distinct feature of Medulla
Medullary cord Medullary Sinuses
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Feature of Medulla where it is brached cord like masses of lymphoid tissue containing both B and T lymphocytes and plasma cells
Medullary cords
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Feature of medulla that is islands of lymphoid tissue
Medullary cords
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Feature of medulla Dilated spaces separating the medullary cords that are continuous with the cortical sinuses.
Medullary sinuses
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Medullay sinuses converge at the hilum of the lymph node to drain into the -------
efferent lymphatic vessels
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Reticular cells and plenty of macrophages are found in the -----
medullary sinuses
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Region of the lymph node containing B lymphocytes and lymphoid nodules
Cortex
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Region of the lymph node containing T lymphocytes, lacks nodules, and has high endothelial venules (HEVs)
Paracortex
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Region of the lymph node containing B and plasma cells, composed of medullary cords and sinuses
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