Vaginal ROA

0.0(0)
Studied by 0 people
call kaiCall Kai
learnLearn
examPractice Test
spaced repetitionSpaced Repetition
heart puzzleMatch
flashcardsFlashcards
GameKnowt Play
Card Sorting

1/9

encourage image

There's no tags or description

Looks like no tags are added yet.

Last updated 8:27 PM on 4/21/26
Name
Mastery
Learn
Test
Matching
Spaced
Call with Kai

No analytics yet

Send a link to your students to track their progress

10 Terms

1
New cards

Obj. 2 (obj. 1 - FYI)

Discuss drug delivery through Vagina.

  • Avoid 1st-pass metabolism

  • Rich vascularization

  • Relatively low enzymatic activity

  • Non-invasive, controlled transmucosal deliver for both local & systemic effects

2
New cards

Obj. 2 (cont.)

Discuss drug delivery through Vagina.

  • What are the vaginal features that affects retention of formulation, its absorption and drug release.

  • pH

  • Enzyme activity

  • Microflora

3
New cards

Obj. 2 (cont.)

Discuss drug delivery through Vagina.

  • What vaginal physiology affects the rate and extent of drug absorption after intravaginal administration?

  • Age

  • Stage in menstrual cycle

  • Formulation factors (penetration enhancer, viscosity, adhesives, etc.)

4
New cards

Obj. 3

Enlist 4 therapeutics application of vaginal drug delivery.

  1. Contraceptives (effective route for hormone delivery)

  2. AIDS/HIV

  3. STDs

  4. Vaginal infections

5
New cards

Obj. 4

List 3 advantages and 3 disadvantages of Vaginal drug delivery.

  • What are the 3 Advantages of vaginal drug delivery?

Advantages

  1. Avoid hepatic 1st-pass metabolism

  2. Minimal systemic effects

  3. Local targeting of drugs to the reproductive organs

6
New cards

Obj. 4

List 3 advantages and 3 disadvantages of Vaginal drug delivery.

  • What are the 3 Disadvantages of vaginal drug delivery?

Disadvantages

  1. Patient incompliance

  2. Local irritation

  3. Variable drug absorption → menstrual cycle, menopause, & pregnancy

7
New cards

Obj. 5

Discuss 2 mechanisms for vaginal drug absorption.

  1. Transcellular (membrane) → lipophilic drug

  2. Paracellular (tight junctions) → Hydrophilic drug

8
New cards

Obj. 6

Describe 3 factors affecting vaginal formulations.

  1. Physiological

  • pH acidic (pH 3.5 - 4.5)

  • Enzymes

  • Micro-flora

  • Cyclic changes

  • Hormone level

  1. Physiochemical (API)

  • Molecular size & weight

  • Partition coefficient (lipophilicity)

  • Ionization

  • Chemical nature

  1. Formulation

  • Viscosity

  • Penetration enhancers

  • Bio-adhesive/mucoadhesive properties

9
New cards

Obj. 7

Describe 3 formulation factors affecting vaginal formulations.

  1. Penetration Enhancers (promote absorption & penetration of drug through vaginal mucosa)

  2. Mucoadhesive agents

  3. Bio-adhesive formulation (Polymers - agents delivering API for extended period @ predictable rate)

10
New cards

Obj. 9 + 10 (obj. 8 - FYI)

Identify systemic & local drug delivery through vaginal route.

  1. Local

  • Vaginal Suppositories

  • Vaginal Douches (vaginal irrigation), sprays, solutions

  • Vaginal gels, creams

  • Vaginal films, patches, rings

  1. Systemic

  • Tablets

  • Capsules

  • Injectables

  • Implants