Lab Values/Drugs

Na (Sodium)

135-145

Serum Osmolality

275-290

Normal range for Serum Osmolality is called…

Isotonic

K (Potassium)

3.5-5

Mg (Magnesium)

1.4-2.2

Total Calcium

9-10.5

Ionized Calcium

4.5-5.6

Phos (Phosphorus)

3-4.5

GFR

~120

BUN

10-20

Pediatric eGFR

Bedside Schwartz (height and SCr)

LOOP Diuretic (Which nephron and inhibits which receptor?)

TAL & NKCC2

THIAZIDE Diuretic (Which nephron and inhibits which receptor?)

DCT & NCC

AMILORIDE (Which nephron and inhibits which receptor?) Channel!

Collecting Duct & ENaC

SPIRONOLACTONE (Which nephron and inhibits which receptor?) Hormone!

blocks the mineralocorticoid (aldosterone) receptor

ACETAZOLDAMIDE (Which nephron and inhibits which receptor?)

PCT & Carbonic Anhydrase Inhibitor (causes metabolic acidosis due to loss of Bicarb)

Where does filtered Glucose get primarily reabsorbed? (bulk reabsorption area - amino acids, lots of Na/H2O)

PCT

Which nephron segment is highly permeable to water but has relatively little solute reabsorption? (aka water can leave)

Descending loop of Henle

Which transporter does the macula densa use to sense NaCl delivery?

NKCC2

Which transporter is a primary active transporter that uses ATP directly?

Na⁺/K⁺-ATPase

Where is the Na⁺/K⁺-ATPase generally located on renal tubular epithelial cells?

Basolateral membrane

Crockcroft-Gault CrCl Equation

(140-age)*kg / 72*SCr (*0.85 female)

IBW (male)

50+(2.3*)

IBW (female)

45.5+(2.3*)

AdjBW

IBW+0.4(ABW-IBW)

what is the equation for calculated serum osmolarity?

(Na * 2) + (glucose/18) + (BUN/2.8)

mCrCl

Urine Creatinine(UCr) * Volume / Serume Creatinine(SCr)