conclusion

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5 Terms

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Aspects

Biogenesis, Function, Mechanism, Biological Impact

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Biogenesis

Involves sequential nuclear and cytoplasmic processing (Drosha, Exportin-5, Dicer, RISC)

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Function

Post-transcriptional gene silencing via translational repression or mRNA degradation

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Mechanism

Guided by seed region complementarity between miRNA and 3′ UTR of target mRNA

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Biological Impact

Controls gene networks affecting development, cell cycle, apoptosis; dysregulation linked to diseas