Cholinergic Agonists and Acetylcholinesterase Inhibitors

Flashcards focusing on key terms and definitions related to cholinergic agonists and acetylcholinesterase inhibitors.

Cholinomimetics

Drugs that mimic the action of acetylcholine by activating cholinergic receptors.

Acetylcholinesterase inhibitors

Drugs that inhibit the enzyme acetylcholinesterase, leading to increased levels of acetylcholine at synapses.

Muscarinic receptors

A type of cholinergic receptor that primarily responds to acetylcholine and mediates various physiological responses.

Nicotinic receptors

A type of cholinergic receptor that is activated by acetylcholine and is found in the neuromuscular junction.

Myasthenia Gravis

An autoimmune disease characterized by weakness in skeletal muscles due to disruptions at the neuromuscular junction.

Reversible inhibitors

Inhibitors that temporarily deactivate acetylcholinesterase, allowing for improved neurotransmission.

SLUDGE-ME

An acronym representing the side effects of cholinergic agents: Salivation, Lacrimation, Urination, Diaphoresis/Defecation, GI Upset, Emesis, Miosis, and Bradycardia.

Varenicline

A partial agonist of nicotinic acetylcholine receptors used for smoking cessation.

Bethanechol

A cholinergic agonist used to treat urinary retention by stimulating bladder contraction.

Donepezil

A reversible cholinesterase inhibitor used in the treatment of Alzheimer's disease.