IBS, GERD, constipation, N/V

Brand, Generic, Dosing, MOA, BBW

Dicyclomine (indication)

IBS

Bentyl (indication)

IBS

Dicyclomine (brand)

Bentyl

Bentyl (generic)

Dicyclomine

Dicyclomine (dosing)

20mg po up to 4x/d 30 min before meals

Bentyl (dosing)

20mg po up to 4x/d 30 min before meals

Dicyclomine/Bentyl (MOA)

inhibition of acetylcholine at postganglionic parasympathetic receptor sites in multiple tissues

Linaclotide (indication)

IBS with constipation

Linzess (indication)

IBS with constipation

Linaclotide (brand)

Linzess

Linzess (generic)

Linaclotide

Linaclotide (dosing)

290mcg po qd on an empty stomach 30 min before the first meal of the day

Linzess (dosing)

290mcg po qd on an empty stomach 30 min before the first meal of the day

Linaclotide/Linzess (MOA)

Linaclotide and its active metabolite bind and agonize guanylate cyclase-C on the luminal surface of intestinal epithelium resulting in increased GI transit

Linaclotide/Linzess (BBW)

risk of serious dehydration in pediatric patients under 2yo

• contraindicated in patients under 2 years of age

Omeprazole (brand)

Prilosec

Prilosec (generic)

Omeprazole

Omeprazole (dosing)

20mg po qd

Prilosec (dosing)

20mg po qd

Omeprazole/Prilosec (MOA)

inhibits H+/K+ ATPase enzyme system at the secretary surface of the gastric parietal cell

Esomeprazole (brand)

Nexium

Nexium (generic)

Esomeprazole

Esomeprazole (dosing)

20mg po qd

Nexium (dosing)

20mg po qd

Esomeprazole/Nexium (MOA)

inhibits K+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell

Famotidine (brand)

Pepcid

Pepcid (generic)

Famotidine

Famotidine (dosing)

20mg po BID

Pepcid (dosing)

20mg po qd

Famotidine/Pepcid (MOA)

competitive inhibition of histamine at H2 receptor of the gastric parietal cells, which inhibits gastric acid secretion

Lansoprazole (brand)

Prevacid

Prevacid (generic)

Lansoprazole

Lansoprazole (dosing)

15mg po qd

Prevacid (dosing)

15mg po qd

Lansoprazole/Prevacid (MOA)

inhibits H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell

Pantoprazole (brand)

Protonix

Protonix (generic)

Pantoprazole

Pantoprazole (dosing)

40mg po qd

Protonix (dosing)

40mg po qd

Pantoprazole/Protonix (MOA)

inhibits H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell

Sucralfate (indication)

duodenal ulcer

Carafate (Indication)

duodenal ulcer

Sucralfate (brand)

Carafate

Carafate (generic)

sucralfate

Sucralfate (dosing)

1g po QID on an empty stomach

Carafate (dosing)

1g po QID on sn empty stomach

Sucralfate/Carafate (MOA)

may form ulcer-adherent complex that covers ulcer site and protects it against further attack by acid, pepsin, and bile

Ursodiol (indication)

gall bladder disease

Actigall (indication)

gallbladder disease

Ursodiol (brand)

Actigall

Actigall (generic)

Ursodiol

Ursodiol (dosing)

300mg po BID with food

Actigall (dosing)

300mg po BID with food

Ursodiol/Actigall (MOA)

dissolves cholesterol containing gall stones. Replaces/displaces toxic concentrations of endogenous hydrophobic bile acids that tend to accumulate in cholestatic liver disease

Lactulose (brand)

Kristalose, Constulose, Enulose

Kristalose, Constulose, Enulose (generic)

Lactulose

Lactulose (dosing)

10-20g po qd

Kristalose, Enulose, Constulose (Dosing)

10-20g po qd

Lactulose/ Enulose, Kristalose, Constulose (MOA)

increases osmotic pressure in colon and increases pH resulting in increased water content of stool

Ondansetron (brand)

Zofran

Zofran (generic)

Ondansetron

Ondansetron (dosing)

8mg po TID

Zofran (dosing)

8mg po TID

Ondansetron/Zofran (MOA)

selective 5-HT3 receptor antagonism