Filling in gaps in lecture notes L13-18 (molecular bio)

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13 Terms

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ATP synthase antibiotics - bedaquiline and oligomycin

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Proton pump inhibitor antibiotics - rotenone and metformin

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burk-lineweaver plot

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Glucocorticoids - nuclear receptors

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PPAR nuclear receptors

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Calcium detectors e.g. for ion channels

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calcium ion channel blockers and diseases they treat - nifedipine

physically blocks the channel for Ca

<p>physically blocks the channel for Ca</p>
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calcium ion channel blockers - memantine and ketamine

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ion channel blockers summary

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Ways to disrupt the GPCR

PTX inhibits binding to GPCR

CTX inhibits GTPase activity

<p>PTX inhibits binding to GPCR</p><p>CTX inhibits GTPase activity</p>
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GEFs and GAPs

Guanine exchange factors induce the exchange of GDP for GTP, switching on the signal

GTPase activating proteins terminate the signal

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Propanolol as a GPCR targeting drug

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