DAY 3 red blood cells, thermoregulation, homeostasis

D. higher than, high

HbF has an oxygen affinity that is — that of HbA. In the absence of any globin chains, heme’s affinity for oxygen would be excessively —

a. act as co enzymes

the cellular role of vitamins is to

c. it is never found in circulation

which of the following statements about the reticulocyte is false?

a. the axial skeleton

Erythropoiesis in the older, normal adult (over 40 yrs) occurs mainly in

c. yolk sac, bone marrow

The site of erythropoiesis changes during development. Embryonic synthesis occurs predominantly in the — and gradually shifts to the — iin the fetus.

a. conjugate bilirubin

which of the following is not a role of the macrophage

c. they manufacture antibodies

The liver plays several vital roles. Which of the following is not a function of hepatocytes

e. hemosiderin

The form of intercellular iron that is less soluble and prone to form visible crystals in iron overload

A. Transferrin

Is the plasma protein carrier for iron

C. Ferritin

a hepatocyte intracellular protein that is bound to iron and is part of the normal "blood iron buffer"

B. ferric

Iron in the +3 state

F. methemoglobin

Hgb with iron in the +3 state

D.ferrous

Iron in the +2 state

c. increased plasma EPO level

an increase in hemolytic rate will eventually result in

A. conjugated

liver disease such as hepatitis may result in elevating levels of circulating — bilirubin

A. unconjucated

Gallstones and blocked biliary secretion may result in elevated levels of circulating — bilirubin.

A. RBC count

Blood viscosity, or “thickness” of blood, is mainly a function of

A. Increased, enhancing

An erythrocyte's biconcave shape is an advantage over a spherical shape because this gives the cell a —surface to volume ratio, - gas exchange.

C. a2Y2

In the embryo, Hb formed is composed of the following chains:

A. Differential inducers, differentiated

The hemocytoblast is considered the stem cell to all future blood cells. Substances, known as — are responsible for directing populations of cells down the various cell lines. The hemocytoblast is considered to be —

A. the patients conjugated bilirubin will be high, bile duct obstruction

patient comes to her physician because she notices her stool has lost its brown appearance and now looks white. Her skin and sclera have a yellow color. Her blood is drawn and sent to the lab for analysis. What predictions could we make about her blood values— and what could be the problem —

A. deviation

The hypothalamus is the site of temperature regulation. If the hypothalamic set point for body temperature is suddenly readjusted to 34C, then the temperature that was earlier considered "normal" (that is, 37) is now perceived by the hypothalamus to be a —

a. Initiate shivering

In the question above, the consequence of the change in set point to 34C will be to

A.body temperature

Which of the following is not increased during exercise induced hyperthermia?

B. gain heat and is at risk of hyperthermia.

Consider a person exposed to high heat and humidity. In this case we would expect the person to:

B. NSAID, arachnoid acid

Prostaglandin Ez synthesis can lead to a change in hypothalamic set point for body temperature. One way to block the synthesis of PGE2 is to take a — and decrease the amount of — that is cleaved into PGE2

B. factor VIII

A 2-year-old boy bruises easily and has previously had bleeding gums. The maternal grandfather has a bleeding disorder. His physical examination shows several small bruises on the legs. Of which coagulation factor would you suspect this patient to be deficient?

D. tissue plasminogen activator

What would be the appropriate therapy for massive pulmonary embolism?

C. coumadin

Which of the following substances cannot prevent coagulation when directly added to a blood sample (i.e., in a test tube)?

A.Decreased Vitamin K absorption; Give patient a shot of Vitamin K

A patient comes to her physician because she notices her stool has lost its brown appearance and now looks white. Her skin and sclera have a yellow color. Her blood is drawn and sent to the lab for analysis. You notice that her PT time is longer than normal. Why can this happen (first response)? and what can you do to help the patient (second response)?

A. heparin, more potent

A patient is undergoing open-heart surgery. His blood is diverted through a heart-lung bypass machine. The tubing is lined with — which binds to anti-thrombin III making it a — thrombin inhibitor

C. Give the child an injection of vitamin K.

A child has eaten a large amount of rat poison. What is the most appropriate action for the physician to take?

D. Thromboxane A2

Which of the following is not a natural, endogenous, anti-coagulant?

B. arachnoid acid, increase

Taking baby aspiring on daily basis will block the ability of COX 1 to leave — into various prostaglandins. this means clotting times will —

C. bile duct obstruction

What condition leads to a deficiency in factor IX that can be corrected by intravenous injection of vitamin K?