IPS1 - [Disperse System] - Suspensions

Disperse system

These are liquid preparations containing undissolved or immiscible drug distributed throughout a vehicle.

● Dispersed Phase

● Dispersing Phase (Dispersion Medium)

● Dispersing Agent

Parts of disperse system

Dispersed phase

[PARTS OF DISPERSE SYSTEM]

This refers to the SUBSTANCE distributed.

Dispersing phase or Dispersion medium

[PARTS OF DISPERSE SYSTEM]

This refers to the VEHICLE used.

Dispersing agent

[PARTS OF DISPERSE SYSTEM]

This refers to the THIRD component.

1 nm to 0.5 μm

[PARTICLE SIZE]

Particle size of COLLOIDAL dispersion

0.5 um to 10 um

[PARTICLE SIZE]

Particle size of FINE dispersions (magmas and gels)

10 um to 50 um

[PARTICLE SIZE]

Particle size of COARSE dispersions (suspensions and emulsions)

Shake well

This should be affixed to the label for SUSPENSIONS/EMULSIONS.

Suspension

This is a two-phase system consisting of finely divided solid (suspensoid) dispersed in a liquid vehicle.

● Dispersed Phase - suspensoid

● Dispersion Medium - liquid

● Dispersing Agent - suspending agent

[SUSPENSION]

Composition of suspension

TRUE

[SUSPENSION]

TRUE OR FALSE:

Highly VISCOUS suspensions have LOW pourability.

Thickening agents

[SUSPENSIONS]

Suspending agents are also known as ____

Suspending agents

[SUSPENSIONS]

These agents are used to stabilized suspensions.

Suspending agents

[SUSPENSIONS]

These agents help in lowering the sedimentation rate of particles in suspension.

● Hydrophilic Colloids

● Inorganic Salts

● Agar, Chondrus (Carrageenan), Gelatin, Pectin, Gelatinized Starch

[SUSPENSIONS]

Types of suspending agents

Hydrophilic colloids

[TYPES OF SUSPENDING AGENTS]

These increase the VISCOSITY of water by binding water molecules.

Hydrophilic colloids

[TYPES OF SUSPENDING AGENTS]

These may support MICROBIAL GROWTH.

● Methylcellulose (NEUTRAL)

● Chitosan (CATIONIC)

[TYPES OF SUSPENDING AGENTS]

Hydrophilic colloids are mainly ANIONIC except ____

Hydrophilic colloids

[TYPES OF SUSPENDING AGENTS]

These are INCOMPATIBLE with quaternary antibacterial agents.

Quaternary antibacterial agents

[TYPES OF SUSPENDING AGENTS]

Hydrophilic colloids are INCOMPATIBLE with ___

Hydrophilic colloids

[TYPES OF SUSPENDING AGENTS]

These are mostly INSOLUBLE in ALCOHOLIC solutions.

Alcoholic solutions

[TYPES OF SUSPENDING AGENTS]

Hydrophilic colloids are mostly INSOLUBLE in ____ solutions.

● Acacia

● Tragacanth

[TYPES OF SUSPENDING AGENTS]

Examples of NATURAL hydrophilic colloids

Acacia

[TYPES OF SUSPENDING AGENTS]

A NATURAL hydrophilic colloid used for INTERNAL preparation.

Acacia

[TYPES OF SUSPENDING AGENTS]

A NATURAL hydrophilic colloid used as 35% mucilage.

35% mucilage

[TYPES OF SUSPENDING AGENTS]

Acacia is a natural hydrophilic colloid used as ___% mucilage.

Acacia

[TYPES OF SUSPENDING AGENTS]

A NATURAL hydrophilic colloid that forms colored complex with organic compounds due to peroxidase.

peroxidase

[TYPES OF SUSPENDING AGENTS]

Acacia is a natural hydrophilic colloid that forms colored complex with organic compounds due to ____.

Tragacanth

[TYPES OF SUSPENDING AGENTS]

A NATURAL hydrophilic colloid which is BETTER than acacia for EXTERNAL and INTERNAL preparation.

Tragacanth

[TYPES OF SUSPENDING AGENTS]

This is a natural hydrophilic colloid used as 5% dispersion in water and DOES NOT contain peroxidase.

5% dispersion

[TYPES OF SUSPENDING AGENTS]

Tragacanth is a natural hydrophilic colloid used as __% dispersion in water and DOES NOT contain peroxidase.

● Methylcellulose

● Carboxymethylcellulose

[TYPES OF SUSPENDING AGENTS]

Examples of SYNTHETIC hydrophilic colloids

● Clays

● Bentonite

● Magnesium aluminum silicate

● Aluminum hydroxide

[TYPES OF SUSPENDING AGENTS]

Examples of INORGANIC SALTS

Bentonite

[TYPES OF SUSPENDING AGENTS]

An INORGANIC salt that is THIXOTROPIC in nature.

Magnesium aluminum silicate

[TYPES OF SUSPENDING AGENTS]

This INORGANIC salt is also known as VEEGUM.

● Agar

● Chondrus (carrageenan)

● Gelatin

● Pectin

● Gelatinized starch

[TYPES OF SUSPENDING AGENTS]

Other substances used as suspending agents

● Oral Suspensions

● Suspensions for Injection

● Ophthalmic Suspensions

● Suspensions for Topical use

[SUSPENSIONS]

Types of suspensions include:

Oral Suspensions

[TYPES OF SUSPENSIONS]

These are ready to use and include DRY POWDERS for reconstitution.

Suspensions for Injection

[TYPES OF SUSPENSIONS]

Particle size must exhibit SYRINGEBILITY.

Ophthalmic suspensions

[TYPES OF SUSPENSIONS]

In ____, particle size must not exceed 10 microns.

not exceed 10 microns

[TYPES OF SUSPENSIONS]

In Ophthalmic suspensions, particle size must not exceed ___ microns.

Suspensions for Topical use

[TYPES OF SUSPENSIONS]

Fine particles are desired to avoid grittiness when applied to the skin.

Suspensions for Topical use

[TYPES OF SUSPENSIONS]

The smaller the particle size, the greater the covering and protective power of the preparation

● Use wide-mouth containers with adequate airspace for shaking and pouring.

● Store in tight containers.

● Protect from freezing, excessive heat, and light.

[SUSPENSIONS]

Packaging and Storage of Suspensions