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Positive and Negative Regulators
work together to control cell division and maintain genetic stability
G0: Resting
The cell is not actively dividing. It is doing its normal job.
G1: Growing
The cell grows, makes proteins, and gets ready to copy its DNA.
S: Copying DNA
The cell copies its DNA, so the new cells will have the same genetic information.
G2: Preparing
The cell checks the DNA and prepares everything needed for division.
Mitosis
The cell divides into two daughter cells. This includes PMAT.
Prophase
Metaphase
Anaphase
Telophase
PMAT
Prophase
Chromosomes become visible and the cell prepares to divide.
Metaphase
Chromosomes line up in the middle.
Anaphase
Chromosomes separate and move to opposite sides.
Telophase
Two new nuclei form.
Change in DNA structure
Altered DNA function
Celular aberration
= Delular Death
Neoplastic change
Proposed Molecular Cause of Cancer:
Proto-oncogene
Anti-oncogene
Genes in DNA
Proto-oncogene
A normal gene that regulates cell growth and division but can become an oncogene when mutated, potentially leading to cancer
Anti-oncogene
tumor suppressor genes, are regular genes that slow down cell division, repair DNA mistakes, or tell cells when to die