Graft-versus-Host Reaction and Autoimmune Diseases

These flashcards summarize key concepts related to Graft-versus-Host Reaction, blood transfusion compatibility, Rh factor incompatibility, and autoimmune diseases.

What is the Graft-versus-Host Reaction mediated by?

Transplanted T lymphocytes.

What is the most common complication of bone marrow transplantation?

Graft-versus-Host Reaction.

Which organ is affected by exfoliative dermatitis in Graft-versus-Host Reaction?

Skin.

What are the two symptoms seen in the intestine during Graft-versus-Host Reaction?

Malabsorption and diarrhea.

What condition in the liver is associated with Graft-versus-Host Reaction?

Jaundice.

What is the role of natural antibodies in blood transfusions concerning the ABO blood group?

They prevent transfusion between blood groups.

What happens in the Rh group that can lead to sensitization?

Formation of antibodies.

Why is crossmatching important before a blood transfusion?

To prevent adverse reactions between donor and recipient blood.

What is a major clinical feature of Rh Factor incompatibility in fetuses?

Hydrops fetalis.

What is erythroblastosis fetalis?

A condition in the fetus caused by Rh incompatibility leading to destruction of red blood cells.

What severe condition can result from icterus gravis neonatorum?

Kernicterus.

What is RhoGAM used for in Rh factor incompatibility?

Immunoprophylaxis to prevent sensitization.

What is a genetic predisposition in the context of autoimmune diseases?

A familial tendency to develop autoimmune diseases due to genetic factors.

What are the HLA haplotypes associated with?

They are often linked to autoimmune diseases.

How do sex differences relate to autoimmune diseases?

Autoimmune diseases are more common in women than men, highlighting the importance of nongenetic factors.

What characterizes an autoimmune disease?

An abnormal response to self-antigens.

What indicators are looked for to diagnose autoimmune diseases?

Presence of autoantibodies, immune mechanisms, and evidence of an immune nature.