steroids chart

corticosteroids

inhibitions of inflammatory response, depress PMN leukocyte and fibroblast migration, stabilize lysosomes at the cell level, reverse cap permeability, reduce cytokine release, reduce # of inflammatory cells

glucocorticoids

betamethaasone, dexamethasone, methylprednisolone, triamcinolone, prednisolone, prednisone, hydrocortisone, cortisone

glucocorticoids

indicated for acute exacerbation of COPD or asthma

decadron

dexamethasone

medrol, solumedrol

methylprednisolone brand

millipred, orapred, prelone

prednisolone brands

solu-cortef, cortef

hydrocortisone brands

cortisone

pro-drug for cortisol

prednisone

pro-drug for prednisolone

hepatic activation

what kind of activation do cortisone and prednisone undergo?

cortisone, hydrocortison

have a short doa

prednisone, prednisolone, methylprednisolone, triamcinolone

4 CTS with intermediate doa

dexamethasone, betamethasone

2 CTS with long doa

IM administration

what increases the doa of CTS

fungal infections and avoid with live vacciens

CI of glucocorticoids

glaucoma, activation of latent infection

what are the precautions associated with glucocorticoids

diuretics

inx with glucocorticoids

prednisolone

common glucocd in PEDS

7-8am

when should glucocds be given?

10-14 days

how long can larger doses of CTS be given?

14 days

use beyond how many days requires a taper to minimize HPA axis suppression

betamethasone, dexamethasone

previousl used during premature labor and fetal distress to promote surfactant production. what do we use now?

mineralocorticoid

fludrocortisone

florinef

fludrocortisone brand

fludrocortisone (florinef)

indicated fro Addison’s disease to treat hypo-natremia

fludrocortisone

has no anti-inflammatory effect—primarily impacts serum sodium/potassium

liver dysfunction

precaution associated with fludrocortisone

hypercortisolism

what is a serious AE of fludrocortisone?

10mg/d

basal rate of secretion of cortisol

250mg/d

physiologic stress secretion of cortisol

25

cortisone potency

20

hydrocortisone potency

5

prednisone and prednisolone potency

4

Methylpred potency

0.75

dexamethasone potency

HC 25, P 5

steroid doses for replacement of deficiency

HC 200-300

steroid use for acute adrenal insufficiency