carbonic anhydrase mechanism

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Last updated 12:34 AM on 10/1/25
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4 Terms

1
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step 1

zinc has three histidine attached to it. the zinc will attack the oxygen of a water molecule

2
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step 2

one of the hydrogens on water will leave leaving a O-. the hydrogen will attach to the other nitrogen of histidine (histidine acts as a proton shuttle

3
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step 3

the negative oxygen will attack the carbon of CO2 breaking one of the C=O bonds.

4
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extra

-histidine acts as a proton shuttle

-residues of aspartate will organize water