Protein Synthesis Inhibitors

What classes of antibiotiocs bind to 30S

What classes of antibiotiocs bind to 30S

Tetracyclines

Aminoglycosides

What classes of antibiotiocs bind to 50S

Macrolides

Synercid/streptogramins

Linezolid

Clindamycin

Resistance to aminoglycosides results from

phosphorylation, acetylation, and adenylation (modify the drug).

Why is there cross resistance across the macrolides, lincosamides, and streptogramin B family of antibiotics?

that this is the MLSb resistance phenotype. The primary cause is methylation of A2058, which is near the binding site for all these antibiotics. The fact that they all bind in a similar site is why you see cross resistance despite the vast differences in structures.

What macrolide maintains affinity for methylated ribosomes (MLSb resistance)

telithromycin

Resistance for older tetracyclines stemmed predominantly via______

efflux pumps
ex: Tetracycline, Doxycycline, Minocycline

which tetracyclines are resistant to efflux

Tigecycline, eravacycline, and omadacycine

tetracycline destructases lead to resistance to _________

all tetracyclines.