Granules (Ansel's Pharmaceutical Dosage Forms 11th edition)

granules

a dosage form composed of dry aggregates of powder particles that may contain one or more APIs

granules

are prepared agglomerates of smaller particles of powder and flows well compared to powders

through wet methods and dry methods

how are granules prepared?

wet method

a method in making a granule in which the powder is moistened then passes through a resulting paste through a screen of the mesh size to produce the desired size of granules

slugging

the compression of a powder or powder mixture into large tablets or slugs on a compressing machine

effervescent granulated salts

are granules or coarse to very coarse powders containing a medicinal agent in a dry mixture usually composed of sodium bicarbonate, citric acid, and tartaric acid

sodium bicarbonate, citric acid, and tartaric acid

what are effervescent granulated salts composed of?

fusion method and wet method

what are the methods in preparing effervescent granulated salts?

granules

they are irregularly shaped dosage forms but may be prepared to be spherical

granules readily lose their firmness and crumble

what is the resulting product when tartaric acid is used alone in making effervescent granulated salts?