citric acid cycle self test

the citric acid cycle is an example of an amphibolic pathway

true

in eukaryotes the enzymes of the citric acid cycle are found in the cytosol

false

citric acid cycle is an anaerobic pathway

false

the only reaction in the citric acid cycle that produces a carbon-carbon bond is catalyzed by citrate synthase

true

the activated form of eukaryotic pyruvate dehydrogenase complex is the phosphorylated form

false

the molecule shown above is a cofactor of

alpha-ketoglutarate dehydrogenase

which of the following enzymes of the citric acid cycle catalyzes an irreversible step

isocitrate dehydrogenase

which of the following conditions decreases the rate of oxidation of acetyl-CoA by the citric acid cycle

a low NAD+/NADH ratio

which enzyme is unique to the glyoxylate cycle

isocitrate lyase

the only reaction of the citric acid cycle that provides substrate level phosphorylation is catalyzed by

succinyl-CoA synthetase

which of the following is not a property of the E1 enzyme of the pyruvate dehydrogenase complex?

binds NAD+ at its active site

which enzyme is unique to the glyoxylate cycle?

malate synthase

which one of the following enzymes of the citric acid cycle catalyzes an irreversible step

citrate synthase

a molecule shown above is a cofactor of

alpha ketoglutarate dehydrogenase

which of the following enzyme mechanisms involves a phosphorylated histidine intermediate?

succinyl-CoA synthetase

which one of the following enzymes of the citric acid cycle catalyzes an irreversible step?

isocitrate dehydrogenase

order the coenzymes according to their involvement in the pyruvate dehydrogenase complex

TPP, lipoamide, coa-sh, FAD, NAD+

in mammalian tissues, isocitrate dehydrogenase is allosterically stimulated by

a high NAD+/NADH ratio

which of the following enzyme activities would not be decreased by a thiamine deficiency?

pyruvate carboxylase

which enzyme is unique to the glyoxylate cycle

isocitrate lyase

fluoroacetate inhibits the citric acid cycle. fluoroacetate is metabolized into a product that inhibits

aconitase

which of the following enzymes catalyzes an oxidative decarboxylation reaction?

isocitrate dehydrogenase

which one of the following enzymes of the citric acid cycle catalyzes an irreversible step

citrate synthase

which of the following enzymes catalyzes an anaplerotic reaction

pyruvate carboxylase

in mammalian tissues, the citric acid cycle is activated by

a high NAD+/NADH ratio

the conversion of citrate into isocitrate by aconitase involves

a dehydration followed by hydration

the molecule shown is

lipoamide

lipoamide is a cofactor of

alpha ketoglutarate dehydrogenase

the molecule shown is

FAD

FAD is a cofactor of

succinate dehydrogenase

choose the correct order the following intermediates according to their formation in the pyruvate dehydrogenase complex.

FADH2, hydroxyethyl-TPP, NADH, acetyl CoA, acetyl-lipoamide

arrange the following enzymes in the order that they function in the citric acid cycle

succinyl CoA synthetase, succinate dehydrogenase, aconitase, fumarase, alpha ketoglutarate dehydrogenase