M5: Manufacturing Pharmacy - Solid Dosage Forms - Part 3

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Oldest method of coating which involves successive coating of sucrose-based solution.

a. Sugar coating

b. Film coating

c. Plastic coating

d. Glass coating

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Hint

a. Sugar coating

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Hint

Time consuming method and causes large increase in weight almost >50%.

a. Sugar coating

b. Film coating

c. Plastic coating

d. Glass coating

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a. Sugar coating

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60 Terms

1

Oldest method of coating which involves successive coating of sucrose-based solution.

a. Sugar coating

b. Film coating

c. Plastic coating

d. Glass coating

a. Sugar coating

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2

Time consuming method and causes large increase in weight almost >50%.

a. Sugar coating

b. Film coating

c. Plastic coating

d. Glass coating

a. Sugar coating

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3

Steps in sugar coating:

1- Color coating

2- Polishing

3- Sealing

4- Subcoating

5- Smoothing

a. 34512

b. 43512

c. 14352

d. 51342

a. 34512

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4

Waterproofing wherein tablet core separates from water.

a. Sealing

b. Sub-coating

c. Smoothing

d. Color coating

e. Polishing

a. Sealing

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5

Seal coating agents except:

a. Shellac

b. Cellulose acetate phthalate (CAP)

c. Polyvinyl acetate phthalate (PVAP)

d. Zein

e. None

e. None

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6

Protein from corn.

a. Shellac

b. Cellulose acetate phthalate (CAP)

c. Polyvinyl acetate phthalate (PVAP)

d. Zein

d. Zein

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7

Rounds off the edges and builds up the tablet size. It is the most critical step.

a. Sealing

b. Sub-coating

c. Smoothing

d. Color coating

e. Polishing

b. Sub-coating

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8

Step that adds the most weight to the tablet.

a. Sealing

b. Sub-coating

c. Smoothing

d. Color coating

e. Polishing

b. Sub-coating

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9

Alternate layers of sticky binder (acacia or gelatin) and dusting powder are agents for:

a. Sealing

b. Sub-coating

c. Smoothing

d. Color coating

e. Polishing

b. Sub-coating

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10

Aka syruping as it use 60-70% syrup.

a. Sealing

b. Sub-coating

c. Smoothing

d. Color coating

e. Polishing

c. Smoothing

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11

Critical step for tablet elegance.

a. Sealing

b. Sub-coating

c. Smoothing

d. Color coating

e. Polishing

d. Color coating

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12

Color coating is usually done with 60-70% syrup + colorant.

a. True

b. False

a. True

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13

Color coating steps that develops color.

a. Grossing

b. Heavy syruping

c. Regular syruping

a. Grossing

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14

Color coating steps that builds up color.

a. Grossing

b. Heavy syruping

c. Regular syruping

b. Heavy syruping

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15

Color coating steps for giving the final color.

a. Grossing

b. Heavy syruping

c. Regular syruping

c. Regular syruping

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16

Optional step.

a. Sealing

b. Sub-coating

c. Smoothing

d. Color coating

e. Polishing

e. Polishing

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17

Polishing agents except:

a. Beeswax

b. Carnauba wax,

c. Candelila wax

d. Hard paraffin wax

e. None

e. None

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18

Involves deposition of thin film of polymer around the tablet core.

a. Sugar coating

b. Film coating

c. Plastic coating

d. Glass coating

b. Film coating

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19

Coating with minimal increase in weight (2-3%) and easier and faster.

a. Sugar coating

b. Film coating

c. Plastic coating

d. Glass coating

b. Film coating

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20

Component of film coating aside from film former except:

a. Plasticizer

b. Surfactant

c. Alloying Substance

d. Glossant

e. Volatile Solvent/Vehicle

f. None

f. None

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21

Produces smooth, thin films.

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

a. Film former

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22

Non enteric film former except:

a. Celluloses

b. Methacrylate

c. PVA

d. PVP

e. None

e. None

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23

Enteric film former except:

a. Shellac

b. Cellulose acetate pthalate

c. Polyvinyl acetate phthalate

d. Salol

e. None

e. None

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24

Produces flexibility and elasticity.

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

b. Plasticizer

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25

Castor oil and glycerin are used as what?

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

b. Plasticizer

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Enhances spreadability of the fill.

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

c. Surfactant

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27

Polysorbates use in film coating.

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

c. Surfactant

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Provides water solubility/ permeability to the film.

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

d. Alloying Substance

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PEG.

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

d. Alloying Substance

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30

Provides luster or shine to the tablets without separate polishing operation.

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

e. Glossant

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Beeswax

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

e. Glossant

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32

Allows the spread of the other components over the tablets.

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

f. Volatile Solvent/Vehicle

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Alcohol + acetone

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

f. Volatile Solvent/Vehicle

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34

Coating defect:

Uneven color distribution due to poor mixing, uneven spray patterns, or migration of additives during drying.

a. Mottling

b. Sweating

c. Bridging

d. Erosion

e. Cratering

f. Blistering

a. Mottling

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Coating defect:

Oily film or droplets of liquid due to humid conditions.

a. Mottling

b. Sweating

c. Bridging

d. Erosion

e. Cratering

f. Blistering

b. Sweating

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Coating defect:

Markings are obscured due to coating solution filling in the logo of the tablet.

a. Mottling

b. Sweating

c. Bridging

d. Erosion

e. Cratering

f. Blistering

c. Bridging

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Coating defect:

Removal of coating from the tablet surface due to friction themselves.

a. Mottling

b. Sweating

c. Bridging

d. Erosion

e. Cratering

f. Blistering

d. Erosion

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38

Coating defect:

Craters appeared exposing the tablet surface due to disruption of coating at the crown when the surface is more porous.

a. Mottling

b. Sweating

c. Bridging

d. Erosion

e. Cratering

f. Blistering

e. Cratering

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39

Coating defect:

Reduced adhesion and detachment of the film due to entrapment of gases underneath the film.

a. Mottling

b. Sweating

c. Bridging

d. Erosion

e. Cratering

f. Blistering

f. Blistering

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40

Coating defect:

Fading or dulling of the film due to high concentration and low MW of plasticizer.

a. Blooming

b. Blushing

c. Twinning

d. Orange Peel

e. Flaking

f. Delayed Distribution

a. Blooming

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41

Coating defect:

Whitish specks or haziness of the film due to precipitation of polymer at high temperature.

a. Blooming

b. Blushing

c. Twinning

d. Orange Peel

e. Flaking

f. Delayed Distribution

b. Blushing

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42

Coating defect:

2 tablets stick together due to inappropriate tablet shape or tracky coating formulation.

a. Blooming

b. Blushing

c. Twinning

d. Orange Peel

e. Flaking

f. Delayed Distribution

c. Twinning

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43

Coating defect:

Rough, non-glossy film surface due to inadequate spreading)

a. Blooming

b. Blushing

c. Twinning

d. Orange Peel

e. Flaking

f. Delayed Distribution

d. Orange Peel

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44

Coating defect remedied by adding polysorbate surfactant.

a. Blooming

b. Blushing

c. Twinning

d. Orange Peel

e. Flaking

f. Delayed Distribution

d. Orange Peel

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45

Due to thermal expansion of tablet cores caused by over drying.

a. Type I flaking

b. Type II flaking

a. Type I flaking

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46

Due to core swelling caused by excessive moisture uptake

a. Type I flaking

b. Type II flaking

b. Type II flaking

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47

Coating defect:

Film cracking

a. Blooming

b. Blushing

c. Twinning

d. Orange Peel

e. Flaking

f. Delayed Distribution

e. Flaking

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48

Coating defect:

Associated with the exposure of tablet cores to coating process conditions rather than a direct effect of the applied coating.

a. Blooming

b. Blushing

c. Twinning

d. Orange Peel

e. Flaking

f. Delayed Distribution

f. Delayed Distribution

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49

Shells are manufactured in a separate operation from filling.

a. Hard gelatin capsules

b. Soft gelatin capsules

a. Hard gelatin capsules

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50

Most common method of manufacturing hard gelatin capsules.

a. Pin method

b. Plate method

c. Rotating die method

a. Pin method

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51

Steps in filling hard gelatin capsules.

1- Joining/closing

2- Ejection

3- Finishing

4- Rectification

5- Separation

6- Filling

a. 213457

b. 123456

c. 345612

d. 456123

d. 456123

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52

Orienting empty shells properly with bodies facing forward.

a. Rectification

b. Separation

c. Filling

d. Joining/closing

e. Ejection

f. Finishing

a. Rectification

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53

HGC sealing technique:

Seals with a band of gelatin

a. Gelatin Banding

b. Heat Welding

c. Thermal Coupling

a. Gelatin Banding

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54

HGC sealing technique:

Fuses cap to body through double wall thickness.

a. Gelatin Banding

b. Heat Welding

c. Thermal Coupling

b. Heat Welding

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55

HGC sealing technique:

Uses liquid wetting agent to lower melting point between cap and body then bonds.

a. Gelatin Banding

b. Heat Welding

c. Thermal Coupling

c. Thermal Coupling

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56

Formed, filled and sealed in a single operation.

a. Hard gelatin capsules

b. Soft gelatin capsules

b. Soft gelatin capsules

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57

Methods of preparing SGC:

Oldest method which uses gelatin sheets.

a. Plate Process

b. Rotary Die Process

c. Reciprocating Die Process

a. Plate Process

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58

Methods of preparing SGC:

Uses gelatin ribbons brought together between 2 rotating dies.

a. Plate Process

b. Rotary Die Process

c. Reciprocating Die Process

b. Rotary Die Process

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59

Methods of preparing SGC:

Uses gelatin ribbons brought together between 2 rotating dies in opposite process.

a. Plate Process

b. Rotary Die Process

c. Reciprocating Die Process

c. Reciprocating Die Process

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60

Norton capsule machine.

a. Plate Process

b. Rotary Die Process

c. Reciprocating Die Process

c. Reciprocating Die Process

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