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Oldest method of coating which involves successive coating of sucrose-based solution.
a. Sugar coating
b. Film coating
c. Plastic coating
d. Glass coating
a. Sugar coating
Time consuming method and causes large increase in weight almost >50%.
a. Sugar coating
b. Film coating
c. Plastic coating
d. Glass coating
a. Sugar coating
Steps in sugar coating:
1- Color coating
2- Polishing
3- Sealing
4- Subcoating
5- Smoothing
a. 34512
b. 43512
c. 14352
d. 51342
a. 34512
Waterproofing wherein tablet core separates from water.
a. Sealing
b. Sub-coating
c. Smoothing
d. Color coating
e. Polishing
a. Sealing
Seal coating agents except:
a. Shellac
b. Cellulose acetate phthalate (CAP)
c. Polyvinyl acetate phthalate (PVAP)
d. Zein
e. None
e. None
Protein from corn.
a. Shellac
b. Cellulose acetate phthalate (CAP)
c. Polyvinyl acetate phthalate (PVAP)
d. Zein
d. Zein
Rounds off the edges and builds up the tablet size. It is the most critical step.
a. Sealing
b. Sub-coating
c. Smoothing
d. Color coating
e. Polishing
b. Sub-coating
Step that adds the most weight to the tablet.
a. Sealing
b. Sub-coating
c. Smoothing
d. Color coating
e. Polishing
b. Sub-coating
Alternate layers of sticky binder (acacia or gelatin) and dusting powder are agents for:
a. Sealing
b. Sub-coating
c. Smoothing
d. Color coating
e. Polishing
b. Sub-coating
Aka syruping as it use 60-70% syrup.
a. Sealing
b. Sub-coating
c. Smoothing
d. Color coating
e. Polishing
c. Smoothing
Critical step for tablet elegance.
a. Sealing
b. Sub-coating
c. Smoothing
d. Color coating
e. Polishing
d. Color coating
Color coating is usually done with 60-70% syrup + colorant.
a. True
b. False
a. True
Color coating steps that develops color.
a. Grossing
b. Heavy syruping
c. Regular syruping
a. Grossing
Color coating steps that builds up color.
a. Grossing
b. Heavy syruping
c. Regular syruping
b. Heavy syruping
Color coating steps for giving the final color.
a. Grossing
b. Heavy syruping
c. Regular syruping
c. Regular syruping
Optional step.
a. Sealing
b. Sub-coating
c. Smoothing
d. Color coating
e. Polishing
e. Polishing
Polishing agents except:
a. Beeswax
b. Carnauba wax,
c. Candelila wax
d. Hard paraffin wax
e. None
e. None
Involves deposition of thin film of polymer around the tablet core.
a. Sugar coating
b. Film coating
c. Plastic coating
d. Glass coating
b. Film coating
Coating with minimal increase in weight (2-3%) and easier and faster.
a. Sugar coating
b. Film coating
c. Plastic coating
d. Glass coating
b. Film coating
Component of film coating aside from film former except:
a. Plasticizer
b. Surfactant
c. Alloying Substance
d. Glossant
e. Volatile Solvent/Vehicle
f. None
f. None
Produces smooth, thin films.
a. Film former
b. Plasticizer
c. Surfactant
d. Alloying Substance
e. Glossant
f. Volatile Solvent/Vehicle
a. Film former
Non enteric film former except:
a. Celluloses
b. Methacrylate
c. PVA
d. PVP
e. None
e. None
Enteric film former except:
a. Shellac
b. Cellulose acetate pthalate
c. Polyvinyl acetate phthalate
d. Salol
e. None
e. None
Produces flexibility and elasticity.
a. Film former
b. Plasticizer
c. Surfactant
d. Alloying Substance
e. Glossant
f. Volatile Solvent/Vehicle
b. Plasticizer
Castor oil and glycerin are used as what?
a. Film former
b. Plasticizer
c. Surfactant
d. Alloying Substance
e. Glossant
f. Volatile Solvent/Vehicle
b. Plasticizer
Enhances spreadability of the fill.
a. Film former
b. Plasticizer
c. Surfactant
d. Alloying Substance
e. Glossant
f. Volatile Solvent/Vehicle
c. Surfactant
Polysorbates use in film coating.
a. Film former
b. Plasticizer
c. Surfactant
d. Alloying Substance
e. Glossant
f. Volatile Solvent/Vehicle
c. Surfactant
Provides water solubility/ permeability to the film.
a. Film former
b. Plasticizer
c. Surfactant
d. Alloying Substance
e. Glossant
f. Volatile Solvent/Vehicle
d. Alloying Substance
PEG.
a. Film former
b. Plasticizer
c. Surfactant
d. Alloying Substance
e. Glossant
f. Volatile Solvent/Vehicle
d. Alloying Substance
Provides luster or shine to the tablets without separate polishing operation.
a. Film former
b. Plasticizer
c. Surfactant
d. Alloying Substance
e. Glossant
f. Volatile Solvent/Vehicle
e. Glossant
Beeswax
a. Film former
b. Plasticizer
c. Surfactant
d. Alloying Substance
e. Glossant
f. Volatile Solvent/Vehicle
e. Glossant
Allows the spread of the other components over the tablets.
a. Film former
b. Plasticizer
c. Surfactant
d. Alloying Substance
e. Glossant
f. Volatile Solvent/Vehicle
f. Volatile Solvent/Vehicle
Alcohol + acetone
a. Film former
b. Plasticizer
c. Surfactant
d. Alloying Substance
e. Glossant
f. Volatile Solvent/Vehicle
f. Volatile Solvent/Vehicle
Coating defect:
Uneven color distribution due to poor mixing, uneven spray patterns, or migration of additives during drying.
a. Mottling
b. Sweating
c. Bridging
d. Erosion
e. Cratering
f. Blistering
a. Mottling
Coating defect:
Oily film or droplets of liquid due to humid conditions.
a. Mottling
b. Sweating
c. Bridging
d. Erosion
e. Cratering
f. Blistering
b. Sweating
Coating defect:
Markings are obscured due to coating solution filling in the logo of the tablet.
a. Mottling
b. Sweating
c. Bridging
d. Erosion
e. Cratering
f. Blistering
c. Bridging
Coating defect:
Removal of coating from the tablet surface due to friction themselves.
a. Mottling
b. Sweating
c. Bridging
d. Erosion
e. Cratering
f. Blistering
d. Erosion
Coating defect:
Craters appeared exposing the tablet surface due to disruption of coating at the crown when the surface is more porous.
a. Mottling
b. Sweating
c. Bridging
d. Erosion
e. Cratering
f. Blistering
e. Cratering
Coating defect:
Reduced adhesion and detachment of the film due to entrapment of gases underneath the film.
a. Mottling
b. Sweating
c. Bridging
d. Erosion
e. Cratering
f. Blistering
f. Blistering
Coating defect:
Fading or dulling of the film due to high concentration and low MW of plasticizer.
a. Blooming
b. Blushing
c. Twinning
d. Orange Peel
e. Flaking
f. Delayed Distribution
a. Blooming
Coating defect:
Whitish specks or haziness of the film due to precipitation of polymer at high temperature.
a. Blooming
b. Blushing
c. Twinning
d. Orange Peel
e. Flaking
f. Delayed Distribution
b. Blushing
Coating defect:
2 tablets stick together due to inappropriate tablet shape or tracky coating formulation.
a. Blooming
b. Blushing
c. Twinning
d. Orange Peel
e. Flaking
f. Delayed Distribution
c. Twinning
Coating defect:
Rough, non-glossy film surface due to inadequate spreading)
a. Blooming
b. Blushing
c. Twinning
d. Orange Peel
e. Flaking
f. Delayed Distribution
d. Orange Peel
Coating defect remedied by adding polysorbate surfactant.
a. Blooming
b. Blushing
c. Twinning
d. Orange Peel
e. Flaking
f. Delayed Distribution
d. Orange Peel
Due to thermal expansion of tablet cores caused by over drying.
a. Type I flaking
b. Type II flaking
a. Type I flaking
Due to core swelling caused by excessive moisture uptake
a. Type I flaking
b. Type II flaking
b. Type II flaking
Coating defect:
Film cracking
a. Blooming
b. Blushing
c. Twinning
d. Orange Peel
e. Flaking
f. Delayed Distribution
e. Flaking
Coating defect:
Associated with the exposure of tablet cores to coating process conditions rather than a direct effect of the applied coating.
a. Blooming
b. Blushing
c. Twinning
d. Orange Peel
e. Flaking
f. Delayed Distribution
f. Delayed Distribution
Shells are manufactured in a separate operation from filling.
a. Hard gelatin capsules
b. Soft gelatin capsules
a. Hard gelatin capsules
Most common method of manufacturing hard gelatin capsules.
a. Pin method
b. Plate method
c. Rotating die method
a. Pin method
Steps in filling hard gelatin capsules.
1- Joining/closing
2- Ejection
3- Finishing
4- Rectification
5- Separation
6- Filling
a. 213457
b. 123456
c. 345612
d. 456123
d. 456123
Orienting empty shells properly with bodies facing forward.
a. Rectification
b. Separation
c. Filling
d. Joining/closing
e. Ejection
f. Finishing
a. Rectification
HGC sealing technique:
Seals with a band of gelatin
a. Gelatin Banding
b. Heat Welding
c. Thermal Coupling
a. Gelatin Banding
HGC sealing technique:
Fuses cap to body through double wall thickness.
a. Gelatin Banding
b. Heat Welding
c. Thermal Coupling
b. Heat Welding
HGC sealing technique:
Uses liquid wetting agent to lower melting point between cap and body then bonds.
a. Gelatin Banding
b. Heat Welding
c. Thermal Coupling
c. Thermal Coupling
Formed, filled and sealed in a single operation.
a. Hard gelatin capsules
b. Soft gelatin capsules
b. Soft gelatin capsules
Methods of preparing SGC:
Oldest method which uses gelatin sheets.
a. Plate Process
b. Rotary Die Process
c. Reciprocating Die Process
a. Plate Process
Methods of preparing SGC:
Uses gelatin ribbons brought together between 2 rotating dies.
a. Plate Process
b. Rotary Die Process
c. Reciprocating Die Process
b. Rotary Die Process
Methods of preparing SGC:
Uses gelatin ribbons brought together between 2 rotating dies in opposite process.
a. Plate Process
b. Rotary Die Process
c. Reciprocating Die Process
c. Reciprocating Die Process
Norton capsule machine.
a. Plate Process
b. Rotary Die Process
c. Reciprocating Die Process
c. Reciprocating Die Process
