CHMA 2002 - Module 2B: AA's peptides and protein

The carboxyl group on an AA can

donate a proton

The amino group of an AA can

accept a proton

At pH = 7.4, amino and carboxyl groups of an AA will

ionize

pH = 7.4 is called

physiological pH

a Zwitterion is

a neutrally charged amino acid after the amino and carboxyl groups are ionized

what AA's have an ionizable R group

the three + charge, 2 - charged, tyrosine, cysteine (7 total)

for a given amino acid with an ionizable group:

pH is the

measure of acidity of solution

pKa is the

acid strength of a compound or a side chain

pKa is equal to pH during a

titration when unprotonated equal protonated

AA's can be weak acids with multiple pka values, meaning they are

polyprotic

the ionizable group with the ____________ pKa will be unprotonated first

lower

the physiological pH is

7.4