Proteins of the Complement System

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17 Terms

1
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Binds to FC region of IgM and IgG

C1q

2
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Activates C1s

C1r

3
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Cleaves C4 and C2

C1s

4
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Part of C3 convertase (C4b)

C4

5
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Binds to C4b—forms C3 convertase

C2

6
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Key intermediate in all pathways

C3

7
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Initiates membrane attack complex

C5

8
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Binds to C5b in MAC

C6

9
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Binds to C5bC6 in MAC

C7

10
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Starts pore formation on membrane

C8

11
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Polymerizes to cause cell lysis

C9

12
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Binds to C3b to form C3 convertase

Factor B

13
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Cleaves factor B

Factor D

14
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Stabilizes C3bBb–C3 convertase

Properdin

15
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Binds to mannose

MBL

16
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Unknown

MASP-1

17
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Cleaves C4 and C2

MASP-2