inheritance of complex diseases

week 8 stibs

simple diseases

• follow Mendelian inheritance patterns: X-linked, autosomal dominant

• generally rare

• caused by changes in one gene

cystic fibrosis

• autosomal recessive

• affects 1 in 2000

• more than 1500 mutations of CFTR gene

key features

• results from action of multiple genes

• alleles of these genes are susceptibility factors

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