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R-
Organometallics
δ–R–MgX
δ–R–Li
δ–R2CuLi
Ar-
ArH
δ–Ar–MgX
δ–Ar–Li
δ–Ar2CuLi

RC(=O)C-H2 (ketone)
RC(=O)CH3 + base for α-deprotonation


ROC(=O)C-H2 (ester)
ROC(=O)CH3 + base for α-deprotonation
